Preoperative diagnosis of multiple intraductal tubulopapillary neoplasms of the pancreas: dynamic imaging features from endoscopic ultrasound
A 60-year-old man with recurrent pancreatitis was admitted to our hospital for further examination and treatment. Abdominal computed tomography highlighted multiple cystic lesions in the pancreas ([Fig. 1 a]). Magnetic resonance imaging revealed atrophic pancreatic parenchyma and segmentally dilated pancreatic duct ([Fig. 1 b]). The diagnosis of intraductal papillary mucinous neoplasm (IPMN) or intraductal tubulopapillary neoplasm (ITPN) was proposed. Subsequent endoscopic ultrasound (EUS) showed multiple cystic lesions with solid tumors inside extending along the dilated main pancreatic duct ([Fig. 1 c]). The intraductal tumor was surrounded by pancreatic fluid in the head of the pancreas, representing the “cork-of-wine-bottle sign;” however, the hypoechoic tumors connecting with anechoic fluids were displayed as two different colors in the dilated duct, indicating the “2-tone duct sign” ([Video 1]). Based on the above two typical imaging findings  , ITPN was reliably diagnosed preoperatively using EUS; thus, surgery was recommended.
Video 1 Preoperative diagnosis of multiple intraductal tubulopapillary neoplasms of the pancreas based on the dynamic imaging features from endoscopic ultrasound, consisting of the “2-tone duct sign” and the “cork-of-wine-bottle sign.”
The resected specimen was identified with solid tumors in the dilated pancreatic duct manifesting as soft and grayish yellow. No mucin was observed. Histopathology showed the tumor consisted of tubulopapillary structures with cylindrical cells and high grade dysplasia ([Fig. 2 a]). On immunohistochemistry, the tumor was negative for MUC2, MUC6, CK-20, and CDX2 ([Fig. 2 b]), and positive for CK7, CAM5.2, and MUC-1 ([Fig. 2 c]). The Ki-67 index reached 70 % ([Fig. 2 c]). The findings were consistent with an ITPN diagnosis.
As a rare pancreatic neoplasm, ITPN is very difficult to diagnose before surgery even with a combination of imaging modes . We report the dynamic imaging features of multiple ITPNs of the pancreas on EUS, including the “2-tone duct sign” and “cork-of-wine-bottle sign.” The limitation of this study is that EUS-guided biopsy may provide more information in the differential diagnosis between IPMN and ITPN  .
Endoscopy E-Videos is a free access online section, reporting on interesting cases and new techniques in gastroenterological endoscopy. All papers include a high
quality video and all contributions are
freely accessible online.
This section has its own submission
* These authors contributed equally to this work.
11. November 2020 (online)
© 2020. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
- 1 Motosugi U, Yamaguchi H, Furukawa T. et al. Imaging studies of intraductal tubulopapillary neoplasms of the pancreas: 2-tone duct sign and cork-of-wine-bottle sign as indicators of intraductal tumor growth. J Comput Assist Tomogr 2012; 36: 710-717
- 2 Zhang J, Ren S, Wang J. et al. Imaging findings of intraductal tubulopapillary neoplasm (ITPN) of the pancreas: two case reports and literature review. Medicine 2019; 98: e14426
- 3 Kuan LL, Dennison AR, Garcea G. Intraductal tubulopapillary neoplasm of the pancreas and bile duct: a review. Pancreas 2020; 49: 498-502
- 4 Huang DC, Bilal M, Gonzalez RS. et al. Not every cyst is an intraductal papillary mucosal neoplasm: a case of intraductal tubulopapillary neoplasm. Gastrointest Endosc 2020; 92: 967-968
- 5 Kovacevic B, Latorre Ano P, Toxvaerd A. et al. Intraductal tubulopapillary neoplasm of the pancreas diagnosed by endoscopic ultrasonography-guided fine needle aspiration. Endoscopy 2017; 49: E266-E267