Drug Res (Stuttg) 2021; 71(04): 199-203
DOI: 10.1055/a-1291-7554
Original Article

Synthesis of Novel Triazolyl/Oxadiazolyl/Thiadiazolyl-Piperazine as Potential Anticonvulsant Agents

Archana Archana
1   Medicinal Chemistry Laboratory, Department of Chemistry, Meerut College, Meerut, Uttar Pradesh, India
› Author Affiliations

Abstract

Reaction of piperazine with chloroacetylchloride in dry acetone yield compound 1 , which on reaction with hydrazine hydrate yielded compound 2, which was further reacted with various substituted phenylisothiocyanates in absolute alcohol to afford compounds 3–8 i. e. 2-(carbazolylacetyl)-N-(substitutedphenyl)-hydrazinepiperazinothioamides. Compounds 3–8 on reaction with aqueous NaOH, ethanolic NaOH and conc. H2SO4 afford triazoles 9–14, oxadiazoles 15–20 and thiadiazoles 21–26 respectively. Twenty four newly synthesized compounds were evaluated for their anticonvulsant activity and acute toxicity. The structures of these compounds were established on the basis of analytical and spectral data.



Publication History

Received: 27 June 2020

Accepted: 12 October 2020

Article published online:
12 January 2021

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