Abstract
The report presents the results of the development of dental films with
ketorolac trometamine based on the natural biodegradable polymers from the
groups of sodium alginates and xanthan gums in combination with lightly
crosslinked acrylic polymer carbopol. Physicochemical properties, such as
moisture, mucoadhesion, thickness, tensile strength, disintegration in
phosphate buffer were determined in obtained samples of this dosage form. A
comparison of physicochemical properties of experimental samples and
commercial model of dental film has allowed establishing the perspective
composition of complex matrix of films with ketorolac trometamine for use in
dentistry.
Keywords
anti-inflammatory drugs - pharmaceutics - drug research - drug delivery
