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Development of Composition and Technologies of Dental Film with Ketorolac TrometamineFunding This research did not receive any financial support.
The report presents the results of the development of dental films with ketorolac trometamine based on the natural biodegradable polymers from the groups of sodium alginates and xanthan gums in combination with lightly crosslinked acrylic polymer carbopol. Physicochemical properties, such as moisture, mucoadhesion, thickness, tensile strength, disintegration in phosphate buffer were determined in obtained samples of this dosage form. A comparison of physicochemical properties of experimental samples and commercial model of dental film has allowed establishing the perspective composition of complex matrix of films with ketorolac trometamine for use in dentistry.
Received: 03 October 2020
Accepted: 26 October 2020
Article published online:
18 November 2020
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- 1 Rajeshwari HR, Dhamecha D, Jagwani S. et al. Local drug delivery systems in the management of periodontitis: A scientific review. J Control Release 2019; 307: 393-409
- 2 Demina NB, Titova AV, Bakhrushina EO. et al. Films as a trend in the creation of innovative medicine delivery systems (review). Vest Roszdravnadzora 2019; 3: 54-58
- 3 El-Feky GS, Farouk Abdulmaguid R, Zayed GM. et al. Mucosal co-delivery of ketorolac and lidocaine using polymeric wafers for dental application. Drug Deliv 2018; 25: 35-42
- 4 Hersh EV, Moore PA, Grosser T. et al. Nonsteroidal anti-inflammatory drugs and opioids in postsurgical dental pain. J Dent Res 2020; 99: 777-786
- 5 Kaladi SR, Tegginmani V, Manoosha M. et al. Effectiveness of pre-operative oral medication of ibuprofen and ketorolac on anesthetic efficacy of inferior alveolar nerve block with irreversible pulpitis: Randomized controlled trial. Cureus 2019; 11: e6346
- 6 Egorova OA. Efficiency and safety of ketorol for the treatment of pain syndrome in outpatient surgical stomatology. Stomatologiia (Mosk) 2009; 88: 53-54
- 7 Sivaramakrishnan G, Sridharan K. Oral ketorolac with inferior alveolar nerve block for irreversible pulpitis: A systematic review and meta-analysis. Open Dent J 2018; 12: 340-346
- 8 Stent D, Drum M, Reader A. et al. Effect of a combination of intranasal ketorolac and nitrous oxide on the success of the inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: A prospective, randomized, double-blind study. J Endod 2018; 44: 9-13
- 9 Akhlaghi N, Azarshab M, Akhoundi N. et al. The effect of ketorolac buccal infiltration on postoperative endodontic pain: A prospective, double-blind, randomized, controlled clinical trial. Quintessence Int 2019; 50: 540-546