Endoscopy 2022; 54(01): 35-44
DOI: 10.1055/a-1327-8357
Original article

Efficacy and safety of cold versus hot snare polypectomy for small (5–9 mm) colorectal polyps: a multicenter randomized controlled trial

1  Department of Gastroenterology, Hospital Universitario Rio Hortega, Valladolid, Spain
,
2  Department of Gastroenterology, Hospital Santos Reyes, Aranda de Duero, Burgos, Spain
,
María Isabel Garcia Martinez
3  Department of Pathology, Complejo Asistencial Universitario de Salamanca, Salamanca, Spain
,
1  Department of Gastroenterology, Hospital Universitario Rio Hortega, Valladolid, Spain
,
Diana Joao Matias
4  Department of Gastroenterology, Complejo Asistencial Universitario de Salamanca, Salamanca, Spain
,
4  Department of Gastroenterology, Complejo Asistencial Universitario de Salamanca, Salamanca, Spain
,
Mercedes Ibáñez
5  Department of Gastroenterology, Hospital de Medina del Campo, Valladolid, Spain
,
1  Department of Gastroenterology, Hospital Universitario Rio Hortega, Valladolid, Spain
,
Marta Cimavilla
6  Department of Gastroenterology, Hospital Río Carrión, Palencia, Spain
,
Carla Tafur
5  Department of Gastroenterology, Hospital de Medina del Campo, Valladolid, Spain
,
Laura Mata
5  Department of Gastroenterology, Hospital de Medina del Campo, Valladolid, Spain
,
Antonio Guardiola-Arévalo
7  Department of Gastroenterology, Hospital Universitario de Fuenlabrada, IdiPAz (Instituto de investigación Hospital Universitario La Paz), Madrid, Spain
,
Jorge Feito
3  Department of Pathology, Complejo Asistencial Universitario de Salamanca, Salamanca, Spain
,
1  Department of Gastroenterology, Hospital Universitario Rio Hortega, Valladolid, Spain
,
on behalf of the POLIPEC HOT-COLD Study Group› Author Affiliations
Supported by: Gerencia Regional de Salud, Junta de Castilla y Leon 1715/A/18

Trial Registration: ClinicalTrials.gov Registration number (trial ID): 03783156 Type of study: Prospective, randomized, multi-center study

Abstract

Background Resection techniques for small polyps include cold snare polypectomy (CSP) and hot snare polypectomy (HSP). This study compared CSP and HSP in 5–9 mm polyps in terms of complete resection and adverse events.

Methods This was a multicenter, randomized trial conducted in seven Spanish centers between February and November 2019. Patients with ≥ 1 5–9 mm polyp were randomized to CSP or HSP, regardless of morphology or pit pattern. After polypectomy, two marginal biopsies were submitted to a pathologist who was blinded to polyp histology. Complete resection was defined as normal mucosa or burn artifacts in the biopsies. Abdominal pain was only assessed in patients without < 5 mm or > 9 mm polyps.

Results 496 patients were randomized: 237 (394 polyps) to CSP and 259 (397 polyps) to HSP. Complete polypectomy rates were 92.5 % with CSP and 94.0 % with HSP (difference 1.5 %, 95 % confidence interval –1.9 % to 4.9 %). Intraprocedural bleeding occurred during three CSPs (0.8 %) and seven HSPs (1.8 %) (P = 0.34). One lesion per group (0.4 %) presented delayed hemorrhage. Post-colonoscopy abdominal pain presented similarly in both groups 1 hour after the procedure (CSP 18.8 % vs. HSP 18.4 %) but was higher in the HSP group after 5 hours (5.9 % vs. 16.5 %; P = 0.02). A higher proportion of patients were asymptomatic 24 hours after CSP than after HSP (97 % vs. 86.4 %; P = 0.01).

Conclusions We observed no differences in complete resection and bleeding rates between CSP and HSP. CSP reduced the intensity and duration of post-colonoscopy abdominal pain.



Publication History

Received: 23 May 2020

Accepted after revision: 02 December 2020

Publication Date:
02 December 2020 (online)

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