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A Stable and Safe Form of Iodine Azide: Polymer-Bound Bisazidoiodate(I)
Received: 28 March 2021
Accepted after revision: 12 April 2021
13 April 2021 (online)
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References and Notes
- 1 Kösel T, Schulz G, Dräger G, Kirschning A. Angew. Chem. Int. Ed. 2020; 59: 12376
- 2 Kirschning A, Monenschein H, Schmeck C. Angew. Chem. Int. Ed. 1999; 38: 2594
- 3 Kirschning A, Jesberger M, Monenschein H. Tetrahedron Lett. 1999; 40: 8999
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- 7 Marinescu LG, Pedersen CM, Bols M. Tetrahedron 2005; 61: 123
- 8 Kösel T, Dräger G, Kirschning A. Org. Biomol. Chem. 2021; 19: 2907
- 9 Pedersen CM, Marinescu LG, Bols M. Org. Biomol. Chem. 2005; 3: 816
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- 11 Preparation of Polymer-Bound Bisazidoiodate(I) 3Amberlyst® A26 resin (4.2 mmol/g hydroxide form) was sequentially rinsed with 1 M NaOH (4 mL g–1 polymer), saturated LiI solution (5 mL g–1 polymer), distilled water (4 mL g–1 polymer), isopropanol (4 mL g–1 polymer), and CH2Cl2 (4 mL g–1 polymer). A suspension of this polymer and PhI(OAc)2 (1.8 equiv) was shaken in dry CH2Cl2 (3 mL g–1 resin) at 665 rpm for 6 h at room temperature under an argon atmosphere. During this time, the reaction mixture was protected from light. The pale-yellow resin 2 was filtered, washed with CH2Cl2 (30 mL g–1 resin), and dried in vacuo. The polymer can be stored for several months under argon atmosphere at –15 °C in the dark without loss of activity. Subsequently, a suspension of this functionalized ion-exchange resin 2 (4.2 mmol anion g–1 resin, 1.0 equiv) and trimethylsilyl azide (2.6 equiv) in dry CH2Cl2 (4 mL/g resin) was shaken at 665 rpm for 6 h at room temperature in the absence of light under an argon atmosphere. The orange resin 3 was filtered, washed with CH2Cl2 (30 mL g–1 resin), and dried in vacuo. In practice, an effective loading of up to 2.1 mmol of reagent g–1 of resin can be achieved. It can be stored for several months under argon atmosphere at –15 °C in the dark without loss of activity.
- 12 It is worth noting that polymer 3, after being evaluated as safety, was commercially available for several years in the early 2000s.
- 13 Note: The number of equivalents for 3 refers to the theoretical loading as specified by the manufacturer of the ion-exchange-resin. The actual amount of IN3 available is much less, therefore the number of equivalents does not describe the true ratio.