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Drug Res (Stuttg) 2022; 72(03): 131-138
DOI: 10.1055/a-1670-6992
Review

An Important Potential Anti-Epileptic/Anticonvulsant Active Group: A Review of 1,2,4-Triazole Groups and Their Action

Ying Wang
1   Public Basic College, Bengbu Medical College, Bengbu, China
,
Dachuan Liu
2   College of pharmacy, Bengbu Medical College, Bengbu, China
› Author Affiliations Funding This work is supported by Joint Science and Technology Project of Bengbu Medical College (BYLK201803), Bengbu Medical College Scientific Research Innovation Team Construction Project (BYKC201904) and Natural Science Fund projects of Bengbu Medical College (BYKY1878).
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Abstract

Epilepsy is one of the most common encountered neurological disorders. Many individuals continue to have seizures despite medical and surgical treatments, suggesting new antiepileptic/anticonvulsant drugs are required. Triazole compounds are widely used in pharmaceuticals and have gained significant importance in medicinal chemistry. This article is an attempt to systematically review the research of triazole derivatives in the design and development of anticonvulsant agents during the past two decades through extensive literature research. The results show that triazole occupy a distinct niche in heterocyclic chemistry and represent a key motif in medicinal chemistry because of their capability to exhibit an array of properties and bioactivities, Therefore, 1,2,4-triazole seems to be an important pharmacophore, especially in the field of antiepileptic, which is of great explored potentiality and utilized value. Through in-depth research on this type of structure, it is believed that more 1,2,4-triazole compounds will be developed as anti-epileptic drugs for clinical use.

Key words

Antiepileptic Drugs - Behavioural Pharmacology - Drug Research - GABA - Chemistry


Publication History

Received: 09 September 2021
Received: 05 October 2021

Accepted: 11 October 2021

Article published online:
10 November 2021

© 2021. Thieme. All rights reserved.

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