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Angewandte Nuklearmedizin 2022; 45(04): 278-285
DOI: 10.1055/a-1712-6250
Nuklearmedizinische Hirnbildgebung
Übersicht

Update diagnostische Bildgebung des dopaminergen Systems

Update Diagnostic Imaging of the Dopaminergic System
Klaus Tatsch
1   Klinik für Nuklearmedizin, Städtisches Klinikum Karlsruhe gGmbH, Karlsruhe, Deutschland
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Zusammenfassung

Die Arbeit gibt ein Update zu dem Einsatz der SPECT- und PET-Bildgebung des prä- und postsynaptischen dopaminergen Systems bei klinisch wichtigen Bewegungsstörungen. Die typischen Untersuchungsbefunde bei neurodegenerativen Parkinson-Syndromen (idiopathisch und nicht-idiopathisch), symptomatischen Parkinson-Syndromen und wichtigen Differentialdiagnosen werden beschrieben. Es wird auf den klinisch praktischen Stellenwert der Methoden eingegangen, deren diagnostische Aussagekraft und Limitationen bewertet, das Thema standardisierter Auswertungen angesprochen und auf die in Leitlinien festgehaltenen Einsatzbereiche Bezug genommen.

Abstract

This paper gives an update on the use of SPECT- and PET-imaging of the pre- and postsynaptic dopaminergic system in the diagnostic work-up of patients with clinically important movement disorders. Typical findings in neurodegenerative parkinsonism (idiopathic and non-idiopathic), in secondary parkinsonism and major differential diagnoses are described. The current clinical impact of the methods with their diagnostic accuracy and limitations are discussed, standardized evaluation methods mentioned, and the role of dopaminergic imaging in current guidelines addressed.

Schlüsselwörter

Single-Photon-Emissions-Computertomografie - Positronen-Emissions-Tomografie - Parkinson-Syndrome - dopaminerges System - Dopamintransporter - Dopaminrezeptoren

Keywords

Single-photon-emission-tomography - positron-emission tomography - movement disorders - dopaminergic system - dopamine transporter - dopamine receptor


Publication History

Article published online:
02 December 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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