Drug Res (Stuttg) 2022; 72(06): 343-349
DOI: 10.1055/a-1830-8701
Original Article

Risperidone Toxicity on Human Blood Lymphocytes in Nano molar Concentrations

Bahareh Sadat Yousefsani
1   Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran
2   School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran
,
Ahmad Salimi
3   Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran
,
Farnaz Imani
4   Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
,
Maral Ramezani
4   Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
,
Kobra Shirani
5   Department of Toxicology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
,
Enayatollah Seydi
6   Department of Occupational Health and Safety Engineering, School of Health, Alborz University of Medical Sciences, Karaj, Iran
7   Research Center for Health, Safety and Environment, Alborz University of Medical Sciences, Karaj, Iran
,
Jalal Pourahmad
4   Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
› Author Affiliations

Abstract

Risperidone is an atypical antipsychotic drug used for the pharmacotherapy of psychiatric disorders. Some reports indicate that risperidone is toxic to various systems of the body, including the immune system. This study evaluated the toxicity effect of risperidone on human blood lymphocytes. To achieve this aim, lymphocytes were isolated using Ficoll paque plus. The results showed that risperidone (12, 24 and 48 nM) causes toxicity in human blood lymphocytes by increasing the level of intracellular reactive oxygen species (ROS), damage to lysosomal membrane, the collapse of the mitochondrial membrane potential (MMP), and increased extracellular oxidized glutathione (GSSG). Also, exposure of human blood lymphocytes to risperidone is associated with a decrease in intracellular glutathione (GSH) levels. Finally, it could be concluded that oxidative stress is one of the mechanisms of risperidone-induced toxicity in human blood lymphocytes.



Publication History

Received: 23 February 2022

Accepted: 19 April 2022

Article published online:
23 May 2022

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