J Am Acad Audiol 2022; 33(05): 301-310
DOI: 10.1055/a-1862-0198
Research Article

The Maturation of the Acoustic Change Complex in Response to Iterated Ripple Noise in ‘Normal’-Hearing Infants, Toddlers, and Adults

S. Strahm
1   School of Audiology and Speech Sciences, The University of British Columbia, Vancouver, Canada
S. A. Small
1   School of Audiology and Speech Sciences, The University of British Columbia, Vancouver, Canada
S. Chan
1   School of Audiology and Speech Sciences, The University of British Columbia, Vancouver, Canada
D. Y. Tian
2   Department of Medicine, The University of Alberta, Edmonton, Canada
M. Sharma
3   Department of Linguistics and The HEARing Cooperative Research Centre , Macquarie University, Sydney, Australia
› Institutsangaben
Funding Research supported by Natural Sciences and Engineering Research Council (NSERC) - Discovery Grant, Canada to Susan A. Small; NSERC Canadian Graduate Scholarship -Master's Program to Stephanie Strahm; Undergraduate Student Research Award to D.Y. Tian; and HEARing CRC, Australia to Mridula Sharma.


Background Infants and toddlers are still being evaluated for their hearing sensitivity but not their auditory-processing skills. Iterated rippled noise (IRN) stimuli require the auditory system to utilize the temporal periodicity and autocorrelate the iterations to perceive pitch.

Purpose This study investigated the acoustic change complex (ACC) elicited by IRN in “normal”-hearing infants, toddlers, and adults to determine the maturation of cortical processing of IRN stimuli.

Design Cortical responses to filtered white noise (onset) concatenated with IRN stimuli (d = 10 milliseconds, gain = 0.7 dB: 4–32 iterations) were recorded in quiet, alert participants.

Study Sample Participants included 25 infants (2.5–15 months), 27 toddlers (22–59 months), and 8 adults (19–25 years) with “normal” hearing sensitivity.

Data Collection and Analysis Cortical auditory-evoked responses were recorded for each participant, including the onset response to the noise and an ACC to the transition from noise to IRN. Group differences were assessed using repeated-measures analyses of variance.

Results Most infants had a replicable onset (P) response, while only about half had a measurable ACC (PACC) response to the high-saliency IRN condition. Most toddlers had onset responses and showed a P-NACC response to the IRN16 and IRN32 conditions. Most of the toddler group had responses present to the onset and showed a P-NACC response to all IRN conditions. Toddlers and adults showed similar P-NACC amplitudes; however, adults showed an increase in N1ACC amplitude with increase in IRN iterations (i.e., increased salience).

Conclusion While cortical responses to the percept of sound as determined by the onset response (P) to a stimulus are present in most infants, ACC responses to IRN stimuli are not mature in infancy. Most toddlers as young as 22 months, however, exhibited ACC responses to the IRN stimuli even when the pitch saliency was low (e.g., IRN4). The findings of the current study have implications for future research when investigating maturational effects on ACC and the optimal choice of stimuli.


Any mention of a product, service, or procedure in the Journal of the American Academy of Audiology does not constitute an endorsement of the product, service, or procedure by the American Academy of Audiology.

Supplementary Material


Eingereicht: 17. Januar 2022

Angenommen: 23. Mai 2022

Accepted Manuscript online:
25. Mai 2022

Artikel online veröffentlicht:
07. November 2022

© 2022. American Academy of Audiology. This article is published by Thieme.

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  • References

  • 1 Oxenham AJ. Pitch perception. J Neurosci 2012; 32 (39) 13335-13338
  • 2 Yost WA. Pitch strength of iterated rippled noise. J Acoust Soc Am 1996; 100 (05) 3329-3335
  • 3 Yost WA, Patterson R, Sheft S. A time domain description for the pitch strength of iterated rippled noise. J Acoust Soc Am 1996; 99 (02) 1066-1078
  • 4 Shearer DE, Molis MR, Bennett KO, Leek MR. Auditory stream segregation of iterated rippled noises by normal-hearing and hearing-impaired listeners. J Acoust Soc Am 2018; 143 (01) 378-387
  • 5 Patterson RD, Handel S, Yost WA, Jaysurya Datta A. The relative strength of the tone and noise components in iterated rippled noise. J Acoust Soc Am 1996; 100 (05) 3286-3294
  • 6 Krumbholz K, Patterson RD, Seither-Preisler A, Lammertmann C, Lütkenhöner B. Neuromagnetic evidence for a pitch processing center in Heschl's gyrus. Cereb Cortex 2003; 13 (07) 765-772
  • 7 Krishnan A, Bidelman GM, Smalt CJ, Ananthakrishnan S, Gandour JT. Relationship between brainstem, cortical and behavioral measures relevant to pitch salience in humans. Neuropsychologia 2012; 50 (12) 2849-2859
  • 8 Patterson RD, Yost WA, Handel S, Datta AJ. The perceptual tone/noise ratio of merged iterated rippled noises. J Acoust Soc Am 2000; 107 (03) 1578-1588
  • 9 Penninger RT, Chien WW, Jiradejvong P, Boeke E, Carver CL, Limb CJ. Perception of pure tones and iterated rippled noise for normal hearing and cochlear implant users. Trends Amplif 2013; 17 (01) 45-53
  • 10 Peter V, Wong K, Narne VK, Sharma M, Purdy SC, McMahon C. Assessing spectral and temporal processing in children and adults using temporal modulation transfer function (TMTF), Iterated Ripple Noise (IRN) perception, and spectral ripple discrimination (SRD). J Am Acad Audiol 2014; 25 (02) 210-218
  • 11 Friesen LM, Tremblay KL. Acoustic change complexes recorded in adult cochlear implant listeners. Ear Hear 2006; 27 (06) 678-685
  • 12 Tremblay KL, Friesen L, Martin BA, Wright R. Test-retest reliability of cortical evoked potentials using naturally produced speech sounds. Ear Hear 2003; 24 (03) 225-232
  • 13 McCarthy KM, Skoruppa K, Iverson P. Development of neural perceptual vowel spaces during the first year of life. Sci Rep 2019; 9 (01) 19592
  • 14 Uhler KM, Hunter SK, Tierney E, Gilley PM. The relationship between mismatch response and the acoustic change complex in normal hearing infants. Clin Neurophysiol 2018; 129 (06) 1148-1160
  • 15 Chen KH, Small SA. Elicitation of the acoustic change complex to long-duration speech stimuli in four-month-old infants. Int J Otolaryngol 2015; 2015: 562030
  • 16 Small SA, Werker JF. Does the ACC have potential as an index of early speech discrimination ability? A preliminary study in 4-month-old infants with normal hearing. Ear Hear 2012; 33 (06) e59-e69
  • 17 Butler BE, Trainor LJ. Brief pitch-priming facilitates infants' discrimination of pitch-evoking noise: evidence from event-related potentials. Brain Cogn 2013; 83 (03) 271-278
  • 18 Hatton JL, Janssen RM, Stapells DR. British Columbia Early Hearing Program. BC Early Hearing Program; 2012: 1687-9201
  • 19 Wunderlich JL, Cone-Wesson BK, Shepherd R. Maturation of the cortical auditory evoked potential in infants and young children. Hear Res 2006; 212 (1-2): 185-202
  • 20 Purdy SC, Sharma M, Munro KJ, Morgan CL. Stimulus level effects on speech-evoked obligatory cortical auditory evoked potentials in infants with normal hearing. Clin Neurophysiol 2013; 124 (03) 474-480
  • 21 Sharma M, Purdy SC, Munro KJ, Sawaya K, Peter V. Effects of broadband noise on cortical evoked auditory responses at different loudness levels in young adults. Neuroreport 2014; 25 (05) 312-319
  • 22 Paus T, Zijdenbos A, Worsley K. et al. Structural maturation of neural pathways in children and adolescents: in vivo study. Science 1999; 283 (5409): 1908-1911
  • 23 Huttenlocher PR, Dabholkar AS. Regional differences in synaptogenesis in human cerebral cortex. J Comp Neurol 1997; 387 (02) 167-178
  • 24 Ponton CW, Eggermont JJ, Kwong B, Don M. Maturation of human central auditory system activity: evidence from multi-channel evoked potentials. Clin Neurophysiol 2000; 111 (02) 220-236
  • 25 Barnet AB. Auditory evoked potentials during sleep in normal children from ten days to three years of age. Electroencephalogr Clin Neurophysiol 1975; 39 (01) 29-41
  • 26 Illing R-B. Maturation and plasticity of the central auditory system. Acta Otolaryngol Suppl 2004; (552) 6-10
  • 27 Lau BK, Werner LA. Perception of the pitch of unresolved harmonics by 3- and 7-month-old human infants. J Acoust Soc Am 2014; 136 (02) 760-767
  • 28 Barker D, Plack CJ, Hall DA. Reexamining the evidence for a pitch-sensitive region: a human fMRI study using iterated ripple noise. Cereb Cortex 2012; 22 (04) 745-753