Semin Neurol 2022; 42(03): 393-402
DOI: 10.1055/a-1887-7104
Review Article

The Curing Coma Campaign and the Future of Coma Research

1   Department of Neurology, University of Texas Southwestern, Dallas, Texas
2   Department of Neurology, University of California San Francisco, San Francisco, California
3   Department of Neurology and Neuroscience, University of Virginia, Charlottesville, Virginia
4   Departments of Neurosurgery and Neurology, University of California, Los Angeles, Los Angeles, California
5   Department of Neurology, Virginia Commonwealth University, Richmond, Virginia
6   Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts
7   Department of Pharmacy Practice, University of Illinois at Chicago, Chicago, Illinois
8   College of Nursing, The Ohio State University, Columbus, Ohio
9   Departments of Anesthesiology and Critical Care Medicine, Neurology, and Neurosurgery; The Johns Hopkins University School of Medicine, Baltimore, Maryland
9   Departments of Anesthesiology and Critical Care Medicine, Neurology, and Neurosurgery; The Johns Hopkins University School of Medicine, Baltimore, Maryland
the Curing Coma Campaign Collaborators › Author Affiliations


Recovery from coma or disordered consciousness is a central issue in patients with acute brain injuries such as stroke, trauma, cardiac arrest, and brain infections. Yet, major gaps remain in the scientific underpinnings of coma and this has led to inaccuracy in prognostication and limited interventions for coma recovery. Even so, recent studies have begun to elucidate mechanisms of consciousness early and prolonged after acute brain injury and some pilot interventions have begun to be tested. The importance and scope of this led in 2019 to the development of the Curing Coma Campaign, an initiative of the Neurocritical Care Society designed to provide a platform for scientific collaboration across the patient care continuum and to empower a community for purposes of research, education, implementation science, and advocacy. Seen as a “grand challenge,” the Curing Coma Campaign has developed an infrastructure of scientific working groups and operational modules, along with a 10-year roadmap.

Publication History

Accepted Manuscript online:
29 June 2022

Article published online:
13 September 2022

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