This article aims to summarizing the evolution of my lab’s research efforts in making
and understanding peptide macrocycles. What started as a curiosity-driven investigation
of amphoteric structures in multicomponent reactions, has turned into a sustained
exploration of complex macrocyclic peptides. As part of this journey, my students
and I have introduced new tools that enable chemical synthesis and property-driven
optimization of cyclic peptides. These contributions are expected to be relevant in
the areas of drug discovery and biological probe design.
Key words
macrocycles - peptides - cellular permeability - heterocycles - amphoteric molecules
