Geburtshilfe Frauenheilkd 2023; 83(01): 49-78
DOI: 10.1055/a-1895-9940
GebFra Science

Recurrent Miscarriage: Diagnostic and Therapeutic Procedures. Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry No. 015/050, May 2022)

Article in several languages: deutsch | English
Bettina Toth
1   Klinik für Gynäkologische Endokrinologie und Reproduktionsmedizin, Universität Innsbruck, Innsbruck, Austria
Michael Bohlmann
2   Zentrum für Gynäkologie und Geburtshilfe, St. Elisabeth Krankenhaus Lörrach, Lörrach, Germany
Katharina Hancke
3   Klinik für Frauenheilkunde, Universitätsklinikum Ulm, Ulm, Germany
Ruben Kuon
4   Universitäts-Frauenklinik Heidelberg, Heidelberg, Germany
Frank Nawroth
5   Amedes, Hamburg, Germany
Sören von Otte
6   Kinderwunschzentrum, Universitätsklinikum Schleswig-Holstein, Kiel, Germany
Nina Rogenhofer
7   Klinikum der Universität München – Frauenklinik Maistraße, München, Germany
Sabine Rudnik-Schöneborn
8   Zentrum für Medizinische Genetik, Universität Innsbruck, Innsbruck, Austria
Ekkehard Schleußner
9   Klinik für Geburtsmedizin, Uniklinikum Jena, Jena, Germany
Clemens Tempfer
10   Universitätsfrauenklinik, Ruhr-Universität Bochum, Bochum, Germany
Kilian Vomstein
1   Klinik für Gynäkologische Endokrinologie und Reproduktionsmedizin, Universität Innsbruck, Innsbruck, Austria
Tewes Wischmann
11   Institut für Medizinische Psychologie, Universitätsklinikum Heidelberg, Heidelberg, Germany
Michael von Wolff
12   Universitätsklinik für Frauenheilkunde, Inselspital Bern, Bern, Switzerland
Wolfgang Würfel
13   Kinderwunsch Centrum München, München, Germany
Johannes Zschocke
8   Zentrum für Medizinische Genetik, Universität Innsbruck, Innsbruck, Austria
› Author Affiliations


Purpose The aim of this guideline is to standardize the diagnosis and therapy of recurrent miscarriage (RM) using evidence from the recent literature. This is done by using consistent definitions, objective evaluations and standardized treatment protocols.

Methods When this guideline was compiled, special consideration was given to previous recommendations in prior versions of this guideline and the recommendations of the European Society of Human Reproduction and Embryology, the Royal College of Obstetricians and Gynecologists, the American College of Obstetricians and Gynecologists and the American Society for Reproductive Medicine, and a detailed individual search of the literature about the different topics was carried out.

Recommendations Recommendations about the diagnostic and therapeutic procedures offered to couples with RM were developed based on the international literature. Special attention was paid to known risk factors such as chromosomal, anatomical, endocrinological, physiological coagulation, psychological, infectious and immune disorders. Recommendations were also developed for those cases where investigations are unable to find any abnormality (idiopathic RM).

Publication History

Received: 28 June 2022

Accepted after revision: 05 July 2022

Article published online:
25 November 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

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