Geburtshilfe Frauenheilkd 2023; 83(03): 267-288
DOI: 10.1055/a-1904-6461
GebFra Science

Gestational and Non-gestational Trophoblastic Neoplasia. Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry No. 032/049, April 2022)

Article in several languages: English | deutsch
Clemens Tempfer
1   Universitätsfrauenklinik der Ruhr-Universität Bochum, Marienhospital Herne, Bochum/Herne, Germany
Lars-Christian Horn
2   Institut für Pathologie, Universitätsklinikum Leipzig, Leipzig, Germany
Sven Ackermann
3   Klinik für Frauenheilkunde und Geburtshilfe, Klinikum Darmstadt, Darmstadt, Germany
Ralf Dittrich
4   Frauenklinik, Universitätsklinikum Erlangen, Erlangen, Germany
Jens Einenkel
5   Klinik für Frauenheilkunde und Geburtshilfe, Sana-Kliniken Leipziger Land, Leipzig, Germany
Andreas Günthert
6   Gyn-Zentrum Luzern, Universität Bern, Bern, Switzerland
Heidemarie Haase
7   Frauenselbsthilfe nach Krebs e. V., Bonn, Germany
Jürgen Kratzsch
8   Institut für Laboratoriumsmedizin, Klinische Chemie und Molekulare Diagnostik, Universitätsklinikum Leipzig, Leipzig, Germany
Michael Kreißl
9   Universitätsklinik für Radiologie und Nuklearmedizin, Klinikum Magdeburg, Magdeburg, Germany
Stephan Polterauer
10   Universitätsfrauenklinik, Medizinische Universität Wien, Wien, Austria
Andreas Ebert
11   Praxis für Gynäkologie und Geburtshilfe, Berlin, Germany
Eric Steiner
12   Frauenklinik, GPR-Klinikum Rüsselsheim, Rüsselsheim, Germany
Falk Thiel
13   Frauenklinik, Klinik am Eichert, Göppingen, Germany
Michael Eichbaum
14   Klinik für Frauenheilkunde und Geburtshilfe, Helios Dr. Horst-Schmidt-Kliniken Wiesbaden, Wiesbaden, Germany
Tanja Fehm
15   Klinik für Frauenheilkunde, Universitätsklinikum Düsseldorf, Düsseldorf, Germany
Martin C. Koch
16   Klinik für Gynäkologie und Geburtshilfe, Ansbach, Germany
Paul Gass
17   Frauenklinik des Universitätsklinikums Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Comprehensive Cancer Center Erlangen/Europäische Metropolregion Nürnberg (CCC ER-EMN), Erlangen, Germany
› Author Affiliations


Purpose The aim was to develop and update a guideline which would improve the quality of care offered to women with gestational and non-gestational trophoblastic disease, a group of diseases characterized by their rarity and biological heterogeneity.

Methods In accordance with the method used to compile S2k-guidelines, the guideline authors carried out a search of the literature (MEDLINE) for the period 1/2020 to 12/2021 and evaluated the recent literature. No key questions were formulated. No structured literature search with methodical evaluation and assessment of the level of evidence was carried out. The text of the precursor version of the guideline from 2019 was updated based on the most recent literature, and new statements and recommendations were drafted.

Recommendations The updated guideline contains recommendations for the diagnosis and therapy of women with hydatidiform mole (partial and complete moles), gestational trophoblastic neoplasia after pregnancy or without prior pregnancy, persistent trophoblastic disease after molar pregnancy, invasive moles, choriocarcinoma, placental site nodules, placental site trophoblastic tumor, hyperplasia at the implantation site und epithelioid trophoblastic tumor. Separate chapters cover the determination and assessment of human chorionic gonadotropin (hCG), histopathological evaluation of specimens, and the appropriate molecular pathological and immunohistochemical diagnostic procedures. Separate chapters on immunotherapy, surgical therapy, multiple pregnancies with simultaneous trophoblastic disease, and pregnancy after trophoblastic disease were formulated, and the corresponding recommendations agreed upon.

Publication History

Received: 12 July 2022

Accepted after revision: 16 July 2022

Article published online:
09 March 2023

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