Subscribe to RSS
DOI: 10.1055/a-1920-1831
Kognition bei Epilepsien im Kindes- und Jugendalter
ZUSAMMENFASSUNG
Kognitive Einschränkungen sind bei etwa jedem fünften Kind mit einer Epilepsie vorhanden. Ein besonders hohes Risiko besteht bei früher Epilepsiemanifestation. Die Ursache der Epilepsie beeinflusst neben anderen Faktoren das Ausmaß der kognitiven Einschränkungen am stärksten. Die Erkennung von kognitiven Einschränkungen bei Kindern mit Epilepsie kann Auswirkungen auf entsprechende Förderkonzepte und Lebenswege für die betroffenen Kinder haben. Ferner muss erkannt werden, ob die medikamentöse Behandlung der Anfälle zu einer eingeschränkten kognitiven Leistungsfähigkeit beiträgt. In einigen Fällen können frühzeitige epilepsiechirurgische Eingriffe, sofern der Patient dafür infrage kommt, einen kognitiven Abbau aufhalten.
Publication History
Article published online:
08 November 2022
© 2022. Thieme. All rights reserved.
Georg Thieme Verlag KG,
Rüdigerstraße 14, 70469 Stuttgart, Germany
-
Literatur
- 1 Bourgeois BF, Prensky AL, Palkes HS. et al Intelligence in epilepsy: a prospective study in children. Ann Neurol 1983; 14: 438-444 DOI: 10.1002/ana.410140407.
- 2 Cheung C, Wirrell E. Adolescents’ perception of epilepsy compared with other chronic diseases: “through a teenager’s eyes”. J Child Neurol 2006; 21: 214-222 DOI: 10.2310/7010.2006.00053.
- 3 Baca CB, Vickrey BG, Caplan R. et al Psychiatric and medical comorbidity and quality of life outcomes in childhood-onset epilepsy. Pediatrics 2011; 128: e1532-1543 DOI: 10.1542/peds.2011-0245.
- 4 Fayed N, Davis AM, Streiner DL. et al Children’s perspective of quality of life in epilepsy. Neurology 2015; 84: 1830-1837 DOI: 10.1212/WNL.0000000000001536.
- 5 Berg AT, Baca CB, Rychlik K. et al Determinants of Social Outcomes in Adults With Childhood-onset Epilepsy. Pediatrics 2016: 137 DOI: 10.1542/peds.2015-3944
- 6 Aldenkamp A, Besag F, Gobbi G. et al Psychiatric and Behavioural Disorders in Children with Epilepsy (ILAE Task Force Report): Adverse cognitive and behavioural effects of antiepileptic drugs in children. Epileptic Disord. 2016 DOI: 10.1684/epd.2016.0817
- 7 Liang S, Wang S, Zhang J. et al Long-term outcomes of epilepsy surgery in school-aged children with partial epilepsy. Pediatr Neurol 2012; 47: 284-290 DOI: 10.1016/j.pediatrneurol 2012.06.014.
- 8 Lee YJ, Lee JS, Kang HC. et al Outcomes of epilepsy surgery in childhood-onset epileptic encephalopathy. Brain Dev 2014; 36: 496-504 DOI: 10.1016/j.braindev.2013.06.010.
- 9 Camfield P, Camfield C. Incidence, prevalence and aetiology of seizures and epilepsy in children. Epileptic Disord 2015; 17: 117-123 DOI: 10.1684/epd.2015.0736.
- 10 Sorg AL, von Kries R, Borggraefe I.. Cognitive disorders in childhood epilepsy: a comparative longitudinal study using administrative healthcare data. J Neurol. 2022 DOI: 10.1007/s00415-022-11008-y
- 11 Berg AT, Langfitt JT, Testa FM. et al Global cognitive function in children with epilepsy: a community-based study. Epilepsia 2008; 49: 608-614 DOI: 10.1111/j.1528-1167.2007.01461.x.
- 12 Berg AT, Berkovic SF, Brodie MJ. et al Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005–2009. Epilepsia 2010; 51: 676-685 DOI: 10.1111/j.1528-1167.2010.02522.x.
- 13 Scheffer IE, Berkovic S, Capovilla G. et al ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017; 58: 512-521 DOI: 10.1111/epi.13709.
- 14 Tacke M, Neubauer BA, Gerstl L. et al Epilepsy-new diagnostic tools, old drugs?: Therapeutic consequences of epilepsy genetics. Nervenarzt 2017; 88: 1385-1394 DOI: 10.1007/s00115-017-0427-7.
- 15 Willimsky EK, Munzig A, Mayer K. et al Next Generation Sequencing in Pediatric Epilepsy Using Customized Panels: Size Matters. Neuropediatrics 2021; 52: 92-97 DOI: 10.1055/s-0040-1712488.
- 16 Dravet C. The core Dravet syndrome phenotype. Epilepsia 2011; 52 (Suppl. 02) 3-9 DOI: 10.1111/j.1528-1167.2011.02994.x.
- 17 Bender AC, Natola H, Ndong C. et al Focal Scn1a knockdown induces cognitive impairment without seizures. Neurobiol Dis 2013; 54: 297-307 DOI: 10.1016/j.nbd.2012.12.021.
- 18 de Lange IM, Gunning B, Sonsma ACM. et al Influence of contraindicated medication use on cognitive outcome in Dravet syndrome and age at first afebrile seizure as a clinical predictor in SCN1A-related seizure phenotypes. Epilepsia 2018; 59: 1154-1165 DOI: 10.1111/epi.14191.
- 19 Nabbout R, Chemaly N, Chipaux M. et al Encephalopathy in children with Dravet syndrome is not a pure consequence of epilepsy. Orphanet J Rare Dis 2013; 08: 176 DOI: 10.1186/1750-1172-8-176.
- 20 Meador KJ. Cognitive outcomes and predictive factors in epilepsy. Neurology 2002; 58: S21-26 DOI: 10.1212/wnl.58.8_suppl_5.s21.
- 21 Moorhouse FJ, Cornell S, Gerstl L. et al Cognitive performance and behavior across idiopathic/genetic epilepsies in children and adolescents. Sci Rep 2020; 10: 21543 DOI: 10.1038/s41598-020-78218-0.
- 22 Lopes AF, Simoes MR, Monteiro JP. et al Intellectual functioning in children with epilepsy: frontal lobe epilepsy, childhood absence epilepsy and benign epilepsy with centro-temporal spikes. Seizure 2013; 22: 886-892 DOI: 10.1016/j.seizure.2013.08.002.
- 23 Nolan MA, Redoblado MA, Lah S. et al Intelligence in childhood epilepsy syndromes. Epilepsy Res 2003; 53: 139-150 DOI: 10.1016/s0920-1211(02)00261-9.
- 24 Rzezak P, Guimaraes CA, Guerreiro MM. et al The impact of intelligence on memory and executive functions of children with temporal lobe epilepsy: Methodological concerns with clinical relevance. Eur J Paediatr Neurol 2017; 21: 500-506 DOI: 10.1016/j.ejpn.2016.12.010.
- 25 Besag FMC, Vasey MJ. Neurocognitive Effects of Antiseizure Medications in Children and Adolescents with Epilepsy. Paediatr Drugs 2021; 23: 253-286 DOI: 10.1007/s40272-021-00448-0.
- 26 Boshuisen K, van Schooneveld MM, Uiterwaal CS. et al Intelligence quotient improves after antiepileptic drug withdrawal following pediatric epilepsy surgery. Ann Neurol 2015; 78: 104-114 DOI: 10.1002/ana.24427.
- 27 Loddenkemper T, Holland KD, Stanford LD. et al Developmental outcome after epilepsy surgery in infancy. Pediatrics 2007; 119: 930-935 DOI: 10.1542/peds.2006-2530.
- 28 Chan S, Pressler R, Boyd SG. et al Does sleep benefit memory consolidation in children with focal epilepsy?. Epilepsia 2017; 58: 456-466 DOI: 10.1111/epi.13668.
- 29 Chan SY. Sleep architecture and homeostasis in children with epilepsy: a neurodevelopmental perspective. Dev Med Child Neurol 2020; 62: 426-433 DOI: 10.1111/dmcn.14437.
- 30 Tacke M, Rupp N, Gerstl L. et al Benign epilepsy with centrotemporal spikes: Correlating spike frequency and neuropsychology. Acta Neurol Scand 2018; 138: 475-481 DOI: 10.1111/ane.13015.
- 31 Ng R, Hodges E. Neurocognitive Profiles of Pediatric Patients with ESES, Generalized Epilepsy, or Focal Epilepsy. Epilepsy Res 2020; 167: 106351 DOI: 10.1016/j.eplepsyres.2020.106351.
- 32 Groppel G, Dorfer C, Dressler A. et al Immediate termination of electrical status epilepticus in sleep after hemispherotomy is associated with significant progress in language development. Dev Med Child Neurol 2017; 59: 89-97 DOI: 10.1111/dmcn.13233.
- 33 Nickels KC, Zaccariello MJ, Hamiwka LD. et al Cognitive and neurodevelopmental comorbidities in paediatric epilepsy. Nat Rev Neurol 2016; 12: 465-476 DOI: 10.1038/nrneurol.2016.98.
- 34 Metz-Lutz MN, Filippini M. Neuropsychological findings in Rolandic epilepsy and Landau-Kleffner syndrome. Epilepsia 2006; 47 (Suppl. 02) 71-75 DOI: 10.1111/j.1528-1167.2006.00695.x.
- 35 Parisi P, Bruni O, Pia Villa M. et al The relationship between sleep and epilepsy: the effect on cognitive functioning in children. Dev Med Child Neurol 2010; 52: 805-810 DOI: 10.1111/j.1469-8749.2010.03662.x.
- 36 Vidaurre J, Twanow JDE. Attention Deficit Hyperactivity Disorder and Associated Cognitive Dysfunction in Pediatric Epilepsy. Semin Pediatr Neurol 2017; 24: 282291 DOI: 10.1016/j.spen.2017.10.009.
- 37 Verrotti A, Moavero R, Panzarino G. et al The Challenge of Pharmacotherapy in Children and Adolescents with Epilepsy-ADHD Comorbidity. Clin Drug Investig 2018; 38: 1-8 DOI: 10.1007/s40261-017-0585-1.
- 38 Auvin S, Wirrell E, Donald KA. et al Systematic review of the screening, diagnosis, and management of ADHD in children with epilepsy. Consensus paper of the Task Force on Comorbidities of the ILAE Pediatric Commission. Epilepsia 2018; 59: 1867-1880 DOI: 10.1111/epi.14549.
- 39 Noachtar S, Borggraefe I. Epilepsy surgery: a critical review. Epilepsy Behav 2009; 15: 66-72 DOI: 10.1016/j.yebeh.2009.02.028.
- 40 Ramantani G, Kadish NE, Strobl K. et al Seizure and cognitive outcomes of epilepsy surgery in infancy and early childhood. Eur J Paediatr Neurol 2013; 17: 498-506 DOI: 10.1016/j.ejpn.2013.03.009.
- 41 Helmstaedter C, Beeres K, Elger CE. et al Cognitive outcome of pediatric epilepsy surgery across ages and different types of surgeries: A monocentric 1-year follow-up study in 306 patients of school age. Seizure 2020; 77: 86-92 DOI: 10.1016/j.seizure.2019.07.021.