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CC BY-NC-ND 4.0 · Endosc Int Open 2023; 11(01): E3-E10
DOI: 10.1055/a-1968-7501
Original article

Endoscopic submucosal dissection using an ultrathin endoscope for superficial pharyngeal cancer: a prospective feasibility study (with video)

Takashi Muramoto
1   Department of Gastrointestinal Endoscopy, NTT Medical Center Tokyo, Tokyo, Japan
,
Ken Ohata
1   Department of Gastrointestinal Endoscopy, NTT Medical Center Tokyo, Tokyo, Japan
,
Eiji Sakai
2   Department of Gastroenterology, Yokohama Sakae Kyosai Hospital, Yokohama, Japan
,
Rikimaru Sawada
1   Department of Gastrointestinal Endoscopy, NTT Medical Center Tokyo, Tokyo, Japan
,
Nao Takeuchi
1   Department of Gastrointestinal Endoscopy, NTT Medical Center Tokyo, Tokyo, Japan
,
Rin Inamoto
1   Department of Gastrointestinal Endoscopy, NTT Medical Center Tokyo, Tokyo, Japan
,
Marie Kurebayashi
1   Department of Gastrointestinal Endoscopy, NTT Medical Center Tokyo, Tokyo, Japan
,
Syunya Takayanagi
1   Department of Gastrointestinal Endoscopy, NTT Medical Center Tokyo, Tokyo, Japan
,
Yoshiaki Kimoto
1   Department of Gastrointestinal Endoscopy, NTT Medical Center Tokyo, Tokyo, Japan
,
Rindo Ishii
1   Department of Gastrointestinal Endoscopy, NTT Medical Center Tokyo, Tokyo, Japan
,
Mako Nohara
1   Department of Gastrointestinal Endoscopy, NTT Medical Center Tokyo, Tokyo, Japan
,
Bo Liu
1   Department of Gastrointestinal Endoscopy, NTT Medical Center Tokyo, Tokyo, Japan
,
Kohei Ono
1   Department of Gastrointestinal Endoscopy, NTT Medical Center Tokyo, Tokyo, Japan
,
Ryoju Negishi
1   Department of Gastrointestinal Endoscopy, NTT Medical Center Tokyo, Tokyo, Japan
,
Yohei Minato
1   Department of Gastrointestinal Endoscopy, NTT Medical Center Tokyo, Tokyo, Japan
,
Hideyuki Chiba
3   Department of Gastroenterology, Omori Red Cross Hospital, Tokyo, Japan
,
Nobuyuki Matsuhashi
4   Department of Gastroenterology, NTT Medical Center Tokyo, Tokyo, Japan
› Author Affiliations TRIAL REGISTRATION: Prospective feasibility study UMIN000040961 at UMIN Japan
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Comment on:

Endoscopy International Open – recently publishedEndoscopy 2023; 55(02): 202-202
DOI: 10.1055/a-1980-1446

Abstract

Background and study aims Endoscopic submucosal dissection (ESD) of pharyngeal cancers with conventional endoscopes often is difficult, not only because of the narrow working space, but also because endoscope maneuverability in the pharynx is poor due to interference from the endotracheal tube and/or hyoid bone. However, we hypothesized that those problems could possibly be resolved by use of an ultrathin endoscope for ESD of superficial pharyngeal cancer. The aim of this prospective interventional study was to investigate the feasibility of ESD for superficial pharyngeal cancer using an ultrathin endoscope.

Patients and methods This feasibility study was conducted at NTT Medical Center Tokyo between June 2020 and September 2021, and data from a total of 20 consecutively superficial pharyngeal cancers were analyzed. The primary outcome measure was the R0 resection rate. The ESD completion rate, en bloc resection rate, procedure time, and frequency of intraoperative and postoperative adverse events (AEs) were also evaluated as secondary outcome measures.

Results Data from 16 patients with 20 lesions were included in the analysis. All of the lesions were successfully resected by ultrathin endoscope ESD, and the en bloc and R0 resection rates were 100 % and 85.0 % (17/20), respectively; the procedure time was 37.8 ± 28.2 minutes. No intraoperative or postoperative AEs were encountered in any cases.

Conclusions ESD using an ultrathin endoscope is feasible for superficial pharyngeal cancers and has potential to be a safe and effective treatment option for these cancers.



Publication History

Received: 18 March 2022

Accepted after revision: 25 October 2022

Accepted Manuscript online:
27 October 2022

Article published online:
04 January 2023

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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