Dedicated to Professor Masahiro Murakami
Abstract
This Account describes the recent advances in our research program toward the development
of cobalt-catalyzed C–H amidation reactions. In particular, synthetic versatilities
of obtainable amino products shown to be achieved on the basis of two distinctive
mechanistic scaffolds; inner- and outer-sphere pathways. It highlights our approaches
to transit the modes of C–N bond formation by introduction of bidentate LX-type ligands
into Cp*Co(III) precursors, thereby broadly expanding the scope of amination reactions.
1 Introduction
2 Cp*Co-Catalyzed Inner-Sphere C–H Amidation
3 Cp*Co-Catalyzed Outer-Sphere C–H Amidation
3.1 C(sp2)–N Bond Formation
3.2 C(sp3)–N Bond Formation
4 Conclusion
Key words
cobalt catalysis - C–H amidation - chelation-assisted amidation - nitrenoid insertion
- site-selective amidation
