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Endoscopy 2023; 55(06): 546-554
DOI: 10.1055/a-1995-2685
Original article

Colorectal sessile serrated lesion detection using linked-color imaging versus narrow-band imaging: a parallel randomized controlled trial

Jun Li
1   Digestive Endoscopy Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China
2   Department of Gastroenterology, Shanghai Tenth People's Hospital Chongming Branch, Shanghai, China
,
Kan Chen
1   Digestive Endoscopy Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China
,
Yunlei Wei
1   Digestive Endoscopy Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China
,
Di Zhang
1   Digestive Endoscopy Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China
,
Yuxin Wang
1   Digestive Endoscopy Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China
,
Xiaojia Hou
1   Digestive Endoscopy Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China
,
Ruijin Wu
1   Digestive Endoscopy Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China
,
Kangsheng Peng
1   Digestive Endoscopy Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China
,
Lei Li
1   Digestive Endoscopy Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China
,
Chao Huang
1   Digestive Endoscopy Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China
,
Yilong Wang
1   Digestive Endoscopy Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China
,
Linjuan Xun
1   Digestive Endoscopy Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China
,
Feng Liu
1   Digestive Endoscopy Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China
2   Department of Gastroenterology, Shanghai Tenth People's Hospital Chongming Branch, Shanghai, China
› Author AffiliationsSupported by: Shanghai Health Commission Scientific Research Project General Program 201940082
Supported by: Shanghai Health Commission Promotion Project for Advanced and Proper Technology 2019SY050

Trial Registration: Chinese Clinical Trial Registry (http://www.chictr.org/) Registration number (trial ID): ChiCTR2100046071 Type of study: Prospective, Parallel, Randomized, Controlled Trial
› Further Information
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Referred to by:

How to optimize the detection of serrated lesions: old tools for a new story?Endoscopy 2023; 55(06): 555-556
DOI: 10.1055/a-2053-8244

Abstract

Background Previous studies have reported the effectiveness of narrow-band imaging (NBI) and linked-color imaging (LCI) in improving the detection of colorectal neoplasms. There has however been no direct comparison between LCI and NBI in the detection of colorectal sessile serrated lesions (SSLs). The present study aimed to compare the effectiveness of LCI and NBI in detecting colorectal SSLs.

Methods A prospective, parallel, randomized controlled trial was conducted. The participants were randomly assigned to the LCI or NBI arms. The primary end point was the SSL detection rate (SDR).

Results 406 patients were involved; 204 in the LCI arm and 202 in the NBI arm. The total polyp detection rate, adenoma detection rate, and SDR were 54.2 %, 38.7 %, and 10.8%, respectively. The SDR was not significantly different between the LCI and NBI arms (12.3 % vs. 9.4 %; P = 0.36). The differences in the detection rate and the per-patient number of polyps, adenomas, diminutive lesions, and flat lesions between LCI and NBI also were not statistically significant. Multivariate analysis showed that LCI and NBI were not independent factors associated with SDR, whereas Boston Bowel Preparation Scale score (odds ratio [OR] 1.35, 95 %CI 1.03–1.76; P = 0.03), withdrawal time (OR 1.13, 95 %CI 1.00–1.26; P = 0.04), and operator experience (OR 3.73, 95 %CI 1.67–8.32; P = 0.001) were independent factors associated with SDR.

Conclusions LCI and NBI are comparable for SSL detection, as well as for the detection of polyps and adenomas.

Supplementary material



Publication History

Received: 03 August 2022

Accepted after revision: 08 December 2022

Accepted Manuscript online:
08 December 2022

Article published online:
22 February 2023

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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