Preparation, Characterization and Evaluation of a Novel Drug Carrier for the Controlled Release of Curcumin

Abstract

The upsurge of cancer demands intense, rapid and effective intervention from the scientific society. Even though nanoparticles helped achieving this, maintaining its size without using toxic capping agents is challenging. Phytochemicals having reducing properties is a proper substitute and the efficiency of such nanoparticles could be further improved by grafting with suitable monomers. It could be further protected from rapid biodegradation by coating with suitable materials. This approach was utilized wherein, the green synthesized silver nanoparticles (AgNps) were initially functionalized with –COOH to couple with –NH₂ groups of ethylene diamine. It was then coated with polyethylene glycol (PEG) and hydrogen bonded with curcumin. The formed amide bonds could effectively uptake drug molecules and sensed environmental pH. Swelling studies and release profiles confirmed selective drug release. All these results along with those obtained from MTT assay, suggested the potential applicability of the prepared material in pH sensitive drug delivery of curcumin.

Key words

Chemotherapy - Curcumin - pH Sensitive Drug Delivery - Silver Nanoparticle

Publication History

Received: 15 July 2022

Accepted: 28 November 2022

Article published online:
21 February 2023

• References

• 1 Yong Q, Kinam P. Environment-sensitive hydrogels for drug delivery. Adv. Drug Delivery Rev 2012; 64: 49-60
• 2 Dirk S. Thermo- and pH-responsive polymers in drug delivery. Adv. Drug Delivery Rev 2006; 58: 1655-1670
• 3 Xu W, Yiqing W, Zhuo GC. et al. Advances of Cancer Therapy by Nanotechnology. Cancer Res. Treat. 2009; 41: 1-11
• 4 Hughes SG. Prescribing for the elderly patient: why do we need to exercise caution?. Br J Clin Pharmacol 1998; 46: 531-533
• 5 Syed AAR, Saleh AM. Applications of nanoparticle systems in drug delivery technology. Saudi Pharm. J. 2018; 26: 64-70
• 6 Bijaideep D, Neena GS, Barack BK. et al. pH sensitive surfactant-stabilized Fe₃O₄ magnetic nano carrier dual drug delivery. Colloids and Surfaces B: Biointerfaces 2018; 163-171
• 7 Xi-Feng Z, Zhi-Guo L, Wei S. et al. Silver Nanoparticles: Synthesis, characterization, properties, applications and therapeutic approaches. Int J Mol Sci 2016; 17: 1534
• 8 Xi-Feng Z, Zhi-Guo L, Wei S. et al. Silver Nanoparticles: Synthesis, Characterization, Properties, Applications and Therapeutic Approaches. Int J Mol Sci 2016; 17: 1534
• 9 Jooyoung S, Haeyoung K, Choonghyeon L. et al Aqueous Synthesis of Silver Nanoparticle Embedded Cationic Polymer Nanofibers and Their Antibacterial Activity. ACS Appl. Mater. Interfaces 2012; 4: 460-465
• 10 Nguyenova HY, Vokata B, Zaruba K. et al. Silver nanoparticles grafted onto PET: Effect of preparation method on antibacterial activity. React. Funct. Polym 2019; 145: 104376-104381
• 11 Sonika D, Saurav K, Aakash G. et al. Current Research on Silver Nanoparticles: Synthesis, Characterization, and Applications. J. Nanomater 2021; 23: 6687290
• 12 Xie M, Shi H, Ma K. et al Hybrid nanoparticles for drug delivery and bioimaging: mesoporous silica nanoparticles functionalized with carboxyl groups and a near-infrared fluorescent dye. J Colloid Interface Sci 2013; 395: 306-314
• 13 Iulia P, Dorina C, Cristina D. et al. Stable PEG-coated silver nanoparticles – A comprehensive toxicological profile. Food Chem. Toxicol 2018; 111: 546-556
• 14 Abhishek G, Sophie M.B.S.S., Hazel G. et al. Synthesis of Silver Nanoparticles Using Curcumin-Cyclodextrins Loaded into Bacterial Cellulose-Based Hydrogels for Wound Dressing Applications. Biomacromolecules 2020; 21: 1802-1811
• 15 Manal A.S, Mohammed M.A, Hesham S. Nanomaterials for application in wound Healing: current state-of-the-art and future perspectives. J. Polym. Res 2022; 29: 91
• 16 Hajtuch J, Hante N, Tomczyk E. et al. Effects of functionalized silver nanoparticles on aggregation of human blood platelets. Int. J. Nanomedicine 2019; 14: 7399-7417
• 17 Jung SS, Qingguo X, Namho K. et al. PEGylation as a strategy for improving nanoparticle-based drug and gene delivery. Adv Drug Deliv Rev 2016; 99: 28-51
• 18 Wing-Hin L, Ching-Yee L, Ramin R. Curcumin and its Derivatives: Their Applications in Neuropharmacology and Neuroscience in the 21st Century. Curr. Neuropharmacol 2013; 338-378
• 19 Garg S, Garg A. Encapsulation of Curcumin in Silver Nanoparticle for Enhancement of Anticancer Drug Delivery. IJPSR 2018; 9: 1160-1166
• 20 Rauwel Protima, Küünal Siim, Ferdov Stanislav. et al. A Review on the Green Synthesis of Silver Nanoparticles and Their Morphologies Studied via TEM. Advances in Materials Science and Engineering 2015; 9: 1-9
• 21 Anirudhan TS, Parvathy J, Nair AS. A novel composite matrix based on polymeric micelle and hydrogel as a drug carrier for the controlled release of dual drugs. Carbohydrate polymers 2016; 136: 1118-1127