Elements-Continuous-Flow Platform for Coupling Reactions and Anti-viral Daclatasvir API Synthesis

Bhushan Mahajan; Dnyaneshwar Aand; Mandeep Purwa; Taufiqueahmed Mujawar; Subhash Ghosh; Srihari Pabbaraja; Ajay K. Singh

doi:10.1055/a-2022-2063

Synthesis, Inhaltsverzeichnis

Synthesis 2024; 56(04): 657-667
DOI: 10.1055/a-2022-2063

special topic

Synthetic Development of Key Intermediates and Active Pharmaceutical Ingredients (APIs)

Elements-Continuous-Flow Platform for Coupling Reactions and Anti-viral Daclatasvir API Synthesis

Autor*innen

Bhushan Mahajan

^aDepartment of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India

^bAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India
Dnyaneshwar Aand

^aDepartment of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India

^bAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India
Mandeep Purwa

^aDepartment of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India

^bAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India
Taufiqueahmed Mujawar

^aDepartment of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India
Subhash Ghosh

^aDepartment of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India

^bAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India
Srihari Pabbaraja ∗

^aDepartment of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India

^bAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India
Ajay K. Singh∗

^aDepartment of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India

^bAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India

Abstract

Alle Artikel dieser Rubrik

Abstract

A novel nanotextured Ni@Cu material embedded electro-microflow reactor with minimal electrode distance has been employed to synthesize biphenyls via the construction of a new C–C bond. The reported protocol is devoid of noble metals and involves co-reductant/oxidant-free conditions in a fast manner for the synthesis of substituted/unsubstituted biphenyl systems. The electro-reactor volume was optimized for gram-scale biphenyl synthesis and further extended for an integrated total process system reducing the tedious downstream process by selective removal of unwanted chemicals/solvent. The continuous microflow synthesis of daclatasvir has now been accomplished with a good yield.

Key words

micro-electro-flow reactor (μ-EFR) - C–C coupling reaction - Ni@Cu coating - daclatasvir API - solvent exchange

Volltext

Referenzen

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