Kinder- und Jugendmedizin 2023; 23(02): 97-102
DOI: 10.1055/a-2029-2210

Diabetische Ketoazidoseraten bei Manifestation eines Typ-1-Diabetes bei Kindern und Jugendlichen in Sachsen

Diabetic ketoacidosis at onset of type 1 diabetes of children and adolescents in Saxony, Germany
Ulf Manuwald
1   Medizinische Fakultät „Carl Gustav Carus” der TU Dresden, IPAS, Gesundheitswissenschaften/Public Health
Olaf Schoffer
2   Universitätsklinikum „Carl Gustav Carus“ der TU Dresden, Zentrum für Evidenzbasierte Gesundheitsversorgung (ZEGV)
Ulrike Rothe
3   GWT an der TU Dresden
Joachim Kugler
1   Medizinische Fakultät „Carl Gustav Carus” der TU Dresden, IPAS, Gesundheitswissenschaften/Public Health
Wieland Kiess
4   Universitätsklinik und Poliklinik für Kinder und Jugendliche Leipzig
› Author Affiliations


Der Typ-1-Diabetes tritt meist schon im Kindes- und Jugendalter auf. Durch die irreversible Störung der Insulinproduktion bei einem neu manifestierten Diabetes Typ 1 kann die für den Körper benötigte Energie nicht mehr aus Glukose gewonnen werden, sondern ersatzweise aus Fett. Infolge des Fettabbaues kann es dann zu einer diabetische Ketoazidose kommen.

Durch Auswertung des Sächsischen Kinder-Diabetes-Registers konnte eine überproportionale Zunahme an diabetischen Ketoazidosen bei Manifestation gegenüber der ebenfalls, aber nur moderat steigenden Typ-1-Diabetes-Inzidenz verzeichnet werden.

Somit ist ein Präventionsprogramm zur Senkung der Ketoazidoseraten bei Manifestation durch Früherkennung eines Typ-1-Diabetes dringend erforderlich.


Type 1 diabetes usually occurs in childhood and adolescence. The associated irreversible disruption of insulin production has the effect that the energy needed by the body cannot be obtained from glucose, but instead from fat as a substitute. The fat breakdown can lead to diabetic ketoacidosis.

Evaluations of the Saxon Child Diabetes Registry showed a disproportionate increase in diabetic ketoacidosis compared to the increasing incidence of type 1 diabetes.

Thus, a prevention program for early detection of type 1 diabetes is urgently needed, which is supposed to be accompanied by a reduction of ketoacidosis rates at manifestation of type 1.

Publication History

Article published online:
19 April 2023

© 2023. Thieme. All rights reserved.

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