Dedicated to Professor Hisashi Yamamoto on the occasion of his 80th birthday
Abstract
Traditional amide linkage forming reactions by the coupling between an acid and an
amine rely primarily on triggering the carboxylic acid counterpart with (over)stoichiometric
activating agent(s) and generate unacceptable quantity of nondisposable waste, leading
to poor atom economy. Herein, we report an efficient catalytic amide synthesis that
proceeds through the in situ activation of the amine counterpart in the form of a
reactive N-formyl amine species. The strategy gives an expedient access to an array of structurally
varied amides, including dipeptides, from numerous genre of acids and amines without
producing stoichiometric solid wastes.
Key words
copper -
N,
N-dimethylformamide - amide coupling - radical reaction
