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CC BY 4.0 · Sustainability & Circularity NOW 2024; 01
DOI: 10.1055/a-2243-0268
Original Article

Continuous Flow Multigram-Scale Synthesis of Cetylpyridinium Chloride

Authors

  • Kashyap Patel

    1   Department of Chemistry, Institute of Chemical Technology, Nathalal Parekh road, Matunga, Mumbai 400019, India

  • Anant R. Kapdi

    1   Department of Chemistry, Institute of Chemical Technology, Nathalal Parekh road, Matunga, Mumbai 400019, India

  • Manish Manohar Shinde

    2   Flow Chemistry Technology (FCT) Hub, Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500046, India

  • Karuna Veeramani

    2   Flow Chemistry Technology (FCT) Hub, Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500046, India

  • Srinivas Oruganti

    2   Flow Chemistry Technology (FCT) Hub, Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500046, India
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Abstract

Cetylpyridinium chloride is popularly employed as an antimicrobial agent in high-volume commodity and consumer products. Given its high tonnage requirements annually, challenges in its synthesis using conventional batch manufacturing involving higher reaction temperatures at scale, lower yields and purity, and excessively long reaction times could be circumvented by adopting continuous flow as a safe and sustainable approach. We herein report a facile, gram-scale continuous flow protocol for the synthesis of cetylpyridinium chloride (CPC) that reduces reaction time from ≥24 hours to 30 minutes with an isolated product yield of >90% and an HPLC purity of >99%.

Keywords

Antimicrobial - Cetylpyridinium chloride - Continuous flow - High-T

Supporting Information



Publikationsverlauf

Eingereicht: 22. Oktober 2023

Angenommen nach Revision: 10. Januar 2024

Artikel online veröffentlicht:
25. Januar 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

Bibliographical Record
Kashyap Patel, Anant R. Kapdi, Manish Manohar Shinde, Karuna Veeramani, Srinivas Oruganti. Continuous Flow Multigram-Scale Synthesis of Cetylpyridinium Chloride. Sustainability & Circularity NOW 2024; 01.
DOI: 10.1055/a-2243-0268
 

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