Drug Res (Stuttg) 2024; 74(03): 93-101
DOI: 10.1055/a-2244-3136
Review

From Hypertension to Beyond: Unraveling the Diverse Mechanisms of Olmesartan in Disease Modulation

Laiba Rind
1   Department of Pharmacology, Faculty of Pharmacy, Integral University, Lucknow, India
3   Department of Pharmacology, Era College of Pharmacy, Era University, Lucknow, India
,
1   Department of Pharmacology, Faculty of Pharmacy, Integral University, Lucknow, India
,
Mohammed Haris Siddiqui
2   Department of Bioengineering, Faculty of Engineering, Integral University, Lucknow, India
,
1   Department of Pharmacology, Faculty of Pharmacy, Integral University, Lucknow, India
,
Arshiya Shamim
1   Department of Pharmacology, Faculty of Pharmacy, Integral University, Lucknow, India
,
Aamir Anwar
1   Department of Pharmacology, Faculty of Pharmacy, Integral University, Lucknow, India
,
Rajnish Kumar Yadav
3   Department of Pharmacology, Era College of Pharmacy, Era University, Lucknow, India
› Author Affiliations
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Abstract

Olmesartan, originally known for its antihypertensive properties, exhibits promising potential in addressing inflammation-mediated diseases. As an angiotensin II receptor blocker (ARB), Olmesartan influences pivotal pathways, including reactive oxygen species, cytokines, NF-κB, TNF-α, and MAPK. This suggests a viable opportunity for repurposing the drug in conditions such as ulcerative colitis, neuropathy, nephropathy, and cancer, as supported by multiple preclinical studies. Ongoing clinical trials, particularly in cardiomyopathy and nephropathy, suggest a broader therapeutic scope for Olmesartan. Repurposing efforts would entail comprehensive investigations using disease-specific preclinical models and dedicated clinical studies. The drug’s established safety profile, wide availability, and well-understood ARB mechanism of action offer distinct advantages that could facilitate a streamlined repurposing process. In summary, Olmesartan’s versatile impact on inflammation-related pathways positions it as a promising candidate for repurposing across various diseases. Ongoing clinical trials and the drug’s favorable attributes enhance its appeal for further exploration and potential application in diverse medical contexts.



Publication History

Received: 09 August 2023

Accepted: 09 January 2024

Article published online:
13 February 2024

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