Osteologie 2024; 33(02): 88-92
DOI: 10.1055/a-2284-5729

Imminent Fracture Risiko – Folgen für die Sequenztherapie

Imminent fracture risk – Consequences for sequential therapy
Friederike Thomasius
1   Frankfurter Hormon- und Osteoporosezentrum, Frankfurt, Germany
Heide Siggelkow
2   MVZ Endokrinologikum Göttingen, Endokrinologikum-Gruppe, Hamburg, Germany
› Author Affiliations


Das „Imminente Frakturrisiko“ war in den vergangenen Jahren Thema diverser Publikationen. Dabei ist das Thema eines akzentuiert erhöht liegenden Frakturrisikos nach Fraktur über einen Zeitraum von max. 2 Jahren nicht neu, da Frakturrisikogradienten nach Fraktur nicht linear mit der Zeit verlaufen. Grund der aufgeflammten Diskussion ist die Möglichkeit der erweiterten therapeutischen Optionen durch Zulassung eines zweiten osteoanabol wirkenden Medikamentes. Die osteoanabole Therapie als optimale Therapiesequenz nach Fraktur in der Zeit des imminent erhöht liegenden Frakturrisikos wird im Konsens international empfohlen. Die Leitlinienaktualisierung der S3 Leitlinie zur Diagnostik und Therapie der Osteoporose fasst die Daten zum imminenten Frakturrisiko in den Empfehlungen zur Differentialtherapie zusammen, der Hintergrund der Empfehlungen soll in dem Beitrag dargelegt werden.


The imminent fracture risk has been the subject of various publications in recent years. The topic of an accentuated increased fracture risk after fractures over a maximum period of 2 years is nothing entirely new, as it has been quite well known that fracture risk gradients after fractures do not run linear over time. The reason for the renewed discussion is the possibility of expanding the therapeutic options through the approval of a second osteoanabolic agent. The international consensus is, that osteoanabolic therapy is the optimal treatment sequence after a fracture during the period of immediately increased fracture risk. The guideline update of the S3 guideline on the diagnosis and treatment of osteoporosis summarizes the data on the imminent fracture risk in the recommendations for differential therapy.

Publication History

Received: 18 December 2023

Accepted: 08 March 2024

Article published online:
16 May 2024

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