Int J Sports Med 2024; 45(13): 958-967
DOI: 10.1055/a-2364-1514
Physiology & Biochemistry

Mitigation of Subsequent Ovariectomy Responses through Prior Exercise Training in Rats

1   Facultad de Ciencias de la Salud de Manresa, UVic-UCC, Vic, Spain
2   Human Movement and Rehabilitation, Post-Graduation Program, Evangelical University of Goiás-UniEVANGÉLICA, Anápolis 75083-515, GO, Brazil
,
Kátia De Angelis
3   Departament of Physiology, Unifesp EPM, Sao Paulo, Brazil
,
Guilherme Lemos Shimojo
3   Departament of Physiology, Unifesp EPM, Sao Paulo, Brazil
,
Marina Rascio Henriques Dutra
3   Departament of Physiology, Unifesp EPM, Sao Paulo, Brazil
,
Camila Paixão dos Santos
3   Departament of Physiology, Unifesp EPM, Sao Paulo, Brazil
,
Nathalia Bernardes
4   Human Moviment Laboratory, Universidade São Judas Tadeu, Sao Paulo, Brazil
,
Andressa Bolsoni-Lopes
5   Department of Nursing, Federal University of Espírito Santo University Radio 104.7 FM, Vitoria, Brazil
,
Rui Curi
6   Interdisciplinary Post-Graduate Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil
,
João Lucas Gomes
7   School of Physical Education and Sports, USP, São Paulo, Brazil
,
Edilamar Menezes Oliveira
7   School of Physical Education and Sports, USP, São Paulo, Brazil
,
Maria Claudia Irigoyen
8   Heart Institute, Heart Institute – InCor, SÃO PAULO, Brazil
,
Christiane Malfitano
9   Department of Health Sciences, Federal University of Lavras, Lavras, Brazil
› Author Affiliations
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Abstract

It is well known that cardiometabolic dysfunction gradually increases after menopause, and the sedentary lifestyle can aggravate this condition. Therefore, we compared the effects of aerobic exercise training during the premenopausal period and after ovariectomy (OVX) on metabolic, hemodynamic, and autonomic parameters in an experimental rat model of menopause. The female rats were divided into four groups: control (C), sedentary OVX (SO), trained OVX (TO), and previously trained OVX (PTO). The PTO group was trained for 4 weeks prior to+8 weeks after OVX, and the TO group trained only after OVX on a motor treadmill. Autonomic modulation was evaluated, white adipose tissue (WAT) was removed and weighed, and lipolysis was assessed. The citrate synthase activity in the soleus muscle was analyzed. The trained groups prevented the impairment of baroreceptor reflex sensitivity in relation to SO; however, only PTO reduced the low-frequency band of the pulse interval compared to SO. PTO reduced the weight of WAT compared to the other groups; lipolysis in PTO was similar to that in C. PTO preserved muscle metabolic injury in all types of fibers analyzed. In conclusion, this study suggests that exercise training should be recommended in a premenopausal model to prevent cardiometabolic and autonomic menopause-induced deleterious effects.



Publication History

Received: 13 July 2023

Accepted: 09 July 2024

Accepted Manuscript online:
10 July 2024

Article published online:
06 August 2024

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