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CC BY 4.0 · Endoscopy 2024; 56(12): 906-912
DOI: 10.1055/a-2386-7843
Original article

Exploring the incidence of dysplasia or adenocarcinoma in early onset Barrett’s esophagus

Irma C. Noordzij 
1   Gastroenterology and Hepatology, Catharina Ziekenhuis, Eindhoven, Netherlands (Ringgold ID: RIN3168)
2   GROW School for Oncology and Reproduction, Maastricht University, Maastricht, Netherlands (Ringgold ID: RIN5211)
,
Clément J. Huysentruyt
3   Pathology, Eurofins PAMM BV Laboratorium voor Pathologie, Eindhoven, Netherlands (Ringgold ID: RIN159178)
,
Wouter L. Curvers
1   Gastroenterology and Hepatology, Catharina Ziekenhuis, Eindhoven, Netherlands (Ringgold ID: RIN3168)
,
Gesina van Lijnschoten
3   Pathology, Eurofins PAMM BV Laboratorium voor Pathologie, Eindhoven, Netherlands (Ringgold ID: RIN159178)
,
Ad A. M. Masclee
4   Gastroenterology and Hepatology, Maastricht University Medical Centre+, Maastricht, Netherlands (Ringgold ID: RIN199236)
,
Erik J. Schoon
1   Gastroenterology and Hepatology, Catharina Ziekenhuis, Eindhoven, Netherlands (Ringgold ID: RIN3168)
5   Onocology, Maastricht University GROW School for Oncology and Reproduction, Maastricht, Netherlands (Ringgold ID: RIN568601)
› Author AffiliationsSupported by: Catharina onderzoeksfonds
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Referred to by:

Early onset Barrettʼs esophagus: new data, new challengesEndoscopy 2024; 56(12): 913-914
DOI: 10.1055/a-2377-9978

Abstract

Background Currently data on the risk of progression to and lifetime risk of cancer are not available for patients with young onset Barrett’s esophagus (BE). Our aim was to obtain epidemiologic data on the incidence of dysplasia or adenocarcinoma in young onset BE in the Netherlands by collecting data on all histologically confirmed cases over a prolonged period of 25 years between January 1, 1991 and December 31, 2015.

Methods Data were obtained from the Dutch National Pathology Registry. Patients were included if there was a suspicion of BE visualized in the esophagus during the endoscopic examination in combination with a concordant histologic diagnosis of intestinal metaplasia.

Results 231 patients with early onset BE were identified (median age 26 years [range 0–29 years]), with 17 progressing to dysplasia (6 prevalent and 11 incident). For the patients with incident dysplasia, the median surveillance time between the diagnosis of early onset BE and diagnosis of dysplasia was 5 years (range 0–16 years). The incidence rate of dysplasia was 7.3 per 1000 person-years. There were three patients who developed adenocarcinoma (1 prevalent and 2 incident), who were diagnosed at ages 28, 35, and 36 years. The incidence rate of adenocarcinoma was 1.3 per 1000 person-years.

Conclusions In this 25-year period, 231 patients were diagnosed with early onset BE in the Netherlands, with 17 patients progressing to dysplasia and three developing adenocarcinoma. This corresponded to incidence rates of 7.3 per 1000 person-years for dysplasia and 1.3 per 1000 person-years for adenocarcinoma.

Supplementary Material



Publication History

Received: 19 October 2023

Accepted after revision: 24 May 2024

Article published online:
23 September 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

 

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