Abstract
This study introduces an efficient, environmentally friendly, and sustainable method
for synthesizing N-acylhydrazone analogues by engaging isoniazid in a condensation reaction with variously
substituted benzaldehydes. The deep-eutectic solvent (ZnCl2/urea) employed in this study acted not only as a solvent but also as a catalyst to
facilitate the synthesis of the target compounds within two to six minutes without
the requirement of any lengthy purification techniques. The synthetic protocol is
operationally simple and offers other remarkable advantages such as a short reaction
time, good to excellent yields, a scalable protocol, and a recyclable and reusable
catalyst. Additionally, green metrics calculations suggest the present method to be
environmentally benign. Finally, the frontier molecular orbitals and the global reactivity
parameters of the synthesized compounds were predicted by using density functional
theory calculations.
Key words
deep-eutectic solvents - acylhydrazones - isoniazid - green chemistry - DFT
