Achieving Sustainability in the Assembly of Modified Nucleosides Using Green Solvents

Mahadev V. Kudalkar; Manisha A. Patel; Yogesh S. Sanghvi; Anant R. Kapdi

doi:10.1055/a-2479-0995

Sustainability & Circularity NOW, Table of Contents

CC BY 4.0 · Sustainability & Circularity NOW 2025; 02: a24790995
DOI: 10.1055/a-2479-0995

Sustainable Solvents

Review

Achieving Sustainability in the Assembly of Modified Nucleosides Using Green Solvents

Authors

Mahadev V. Kudalkar‡

¹Department of Chemistry, Institute of Chemical Technology, Nathalal Parekh Road, Matunga, Mumbai 400019, India
Manisha A. Patel‡

¹Department of Chemistry, Institute of Chemical Technology, Nathalal Parekh Road, Matunga, Mumbai 400019, India
Yogesh S. Sanghvi

²Rasayan Inc., 2802, Crystal Ridge, Encinitas, CA 92024-6615, USA
Anant R. Kapdi

¹Department of Chemistry, Institute of Chemical Technology, Nathalal Parekh Road, Matunga, Mumbai 400019, India

Abstract

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Abstract

Chemical modifications of nucleosides have been a topic of special interest for researchers, given the plethora of applications these structural motifs have been able to demonstrate. For decades, such modifications have been performed in conventional volatile organic solvents that have severe environmental implications. A recent trend suggests a shift in the strategy, with many researchers using sustainable and green solvents such as ionic liquids (ILs), H₂O, deep eutectic solvents (DES), and 2-MeTHF for performing key transformations on the nucleoside’s structural motif. This review critically analyzes examples of nucleoside functionalization carried out in different sustainable solvents and also helps to assess the feasibility of such solvent choices for further applications.

Keywords

Nucleosides - Sustainable solvents - Green solvents - Chemical functionalization - Deep eutectic solvents - Ionic liquids - Suzuki–Miyaura cross-coupling - Amination

Bibliographical Record
Mahadev V. Kudalkar, Manisha A. Patel, Yogesh S. Sanghvi, Anant R. Kapdi. Achieving Sustainability in the Assembly of Modified Nucleosides Using Green Solvents. Sustainability & Circularity NOW 2025; 02: a24790995.
DOI: 10.1055/a-2479-0995

Full Text

References

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