PDF herunterladen
Open Access
CC BY-NC-ND 4.0 · Endosc Int Open 2025; 13: a24872937
DOI: 10.1055/a-2487-2937
Innovation forum

GLP-1 receptor agonist use does not increase risk of respiratory complications post-endoscopy

Authors

  • Jena Velji-Ibrahim

    1   Internal Medicine, Prisma Health Upstate, Greenville, United States (Ringgold ID: RIN3626)
    2   Internal Medicine, University of South Carolina School of Medicine Greenville Campus, Greenville, United States (Ringgold ID: RIN368074)

  • Piyush Nathani

    3   Gastroenterology, The University of Kansas Medical Center, Kansas City, United States (Ringgold ID: RIN21638)

  • Harsh K Patel

    3   Gastroenterology, The University of Kansas Medical Center, Kansas City, United States (Ringgold ID: RIN21638)

  • Prateek Sharma

    3   Gastroenterology, The University of Kansas Medical Center, Kansas City, United States (Ringgold ID: RIN21638)
    4   Gastroenterology, Kansas City VA Medical Center, Kansas City, United States (Ringgold ID: RIN20044)
Weitere Informationen
Auch verfügbar auf
  Lizenzen und Reprints
Preview

Abstract

Background and study aims

Data on respiratory complications associated with GLP-1 receptor agonist (GLP-1 RA) use before endoscopic procedures are limited.

Patients and methods

We conducted a retrospective cohort study using TriNetX in adults with diabetes or obesity on GLP-1 RAs within 3 months of endoscopy, comparing them with non-GLP-1 RA users. Propensity score matching and Cox proportional hazards models were used to assess outcomes.

Results

Among 46,948 patients, no significant differences in post-endoscopy aspiration pneumonitis (hazard ratio [HR] 0.92, 95% confidence interval [CI] 0.54–1.56) or pneumonia (HR 1.01, 95% CI 0.83–1.24) were found between groups.

Conclusions

GLP-1 RA use before endoscopy does not increase respiratory complications, supporting continued preoperative medication use.

Keywords

Quality and logistical aspects - Performance and complications - Preparation - Endoscopy Upper GI Tract - Endoscopy Lower GI Tract

Supplementary Material



Publikationsverlauf

Eingereicht: 21. Oktober 2024

Angenommen nach Revision: 21. November 2024

Accepted Manuscript online:
25. November 2024

Artikel online veröffentlicht:
13. Januar 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

Bibliographical Record
Jena Velji-Ibrahim, Piyush Nathani, Harsh K Patel, Prateek Sharma. GLP-1 receptor agonist use does not increase risk of respiratory complications post-endoscopy. Endosc Int Open 2025; 13: a24872937.
DOI: 10.1055/a-2487-2937
 

  • References

  • 1 Garvey WT, Mechanick JI, Brett EM. et al. American Association of Clinical Endocrinologists and American College of Endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity. Endocr Pract 2016; 22: 842-884
    Suche in Google Scholar
  • 2 Nauck MA, Quast DR, Wefers J. et al. GLP-1 receptor agonists in the treatment of type 2 diabetes- state-of-the-art. Mol Metab 2021; 46: 101102
    Suche in Google Scholar
  • 3 Hashash JG, Thompson CC, Wang AY. AGA rapid clinical practice update on the management of patients taking GLP-1 receptor agonists prior to endoscopy: Communication. Clin Gastroenterol Hepatol 2024; 22: 705-707
    Suche in Google Scholar
  • 4 Joshi GP, Abdelmalak BB, Weigel WA. et al. American Society of Anesthesiologists consensus-based guidance on preoperative management of patients (adults and children) on glicagon-like-peptide-1 (GLP-1) receptor agonists.. https://www.asahq.org/about-asa/newsroom/news-releases/2023/06/american-society-of-anesthesiologists-consensus-based-guidance-on-preoperative.
  • 5 Sen S, Potnuru PP, Hernandez N. et al. Glucagon-like peptide-1 receptor agonist use and residual gastric content before anesthesia. JAMA Surg 2024; 2024: e240111
    Suche in Google Scholar
  • 6 Yeo YH, Gaddam S, Ng WH. Increased risk of aspiration pneumonia associated with endoscopic procedures among patients with glucagon-like peptide 1 receptor agonist use. Gastroenterology 2024; 167: 402-404 e3
    Suche in Google Scholar
  • 7 Tewfik GL, Rodriguez-Aponte C, Zhang K. et al. Outcomes and disposition of patients after case cancellation on day of surgery for reasons attributed to medial or anesthetic care: A retrospective cohort analysis. Anesth Analg 2022; 35: 845-854
    Suche in Google Scholar
  • 8 Childers CP, Maggard-Gibbons M. Understanding costs of care in the operating room. JAMA Surg 2018; 153: e176233
    Suche in Google Scholar
  • 9 von Elm E, Altman DG, Egger M. et al. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: Guidelines for reporting observational studies. J Clin Epidemiol 2008; 61: 344-349
    Suche in Google Scholar
  • 10 Dixit AA, Bateman BT, Hawn MT. et al. Preoperative GLP-1 receptor agonist use and risk of postoperative respiratory complications. JAMA 2024; 331: 1672-1673
    Suche in Google Scholar