Download PDF
Zeitschrift für Ganzheitliche Tiermedizin 2025; 39(01): 18-23
DOI: 10.1055/a-2499-6098
Phytotherapie

Jenseits der antinutritiven Eigenschaften von Gerbstoffen – Neue Untersuchungen zur Wirkung an Ferkeln

Jakub P. Piwowarski
› Further Information
Also available at
    Permissions and Reprints All articles of this category

Gerbstoffhaltige Pflanzenstoffe galten in der Ferkelernährung lange als problematisch, könnten aber eine neue Rolle spielen. Angesichts wachsender Resistenzen durch Antibiotikaeinsatz rückt ihre antidiarrhöische und antimikrobielle Wirkung in den Fokus. Fortschritte in der Forschung und präzise Dosierung eröffnen neue Strategien für die Darmgesundheit von Ferkeln.



Publication History

Article published online:
03 March 2025

© 2025. Thieme. All rights reserved.

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

 

  • Literatur

  • 1 Adamczyk B, Simon J, Kitunen V. et al. Tannins and their complex interaction with different organic nitrogen compounds and enzymes: Old paradigms versus recent advances. ChemistryOpen 2017; 6: 610-614
    CrossrefPubMedSearch in Google Scholar
  • 2 Antongiovanni M, Minieri S, Petacchi F. Effect of tannin supplementation on nitrogen digestibility and retention in growing pigs. Ital J Anim Sci 2007; 6: 245-247
    CrossrefSearch in Google Scholar
  • 3 Auzanneau C, Montaudon D, Jacquet R. et al. The polyphenolic ellagitannin vescalagin acts as a preferential catalytic inhibitor of the alpha isoform of human DNA topoisomerase II. Mol Pharmacol 2012; 82: 134-141
    CrossrefPubMedSearch in Google Scholar
  • 4 Bobowska A, Granica S, Filipek A. et al Comparative studies of urolithins and their phase II metabolites on macrophage and neutrophil functions. Eur J Nutr 2020; in press
    CrossrefPubMedSearch in Google Scholar
  • 5 Bruins MJ, Vente-Spreeuwenberg MA, Smits CH, Frenken LG. Black tea reduces diarrhoea prevalence but decreases growth performance in enterotoxigenic Escherichia coli-infected post-weaning piglets. J Anim Physiol Anim Nutr (Berl) 2011; 95: 388-398
    CrossrefPubMedSearch in Google Scholar
  • 6 Butler LG. Antinutritional effects of condensed and hydrolyzable tannins. Basic Life Sci 1992; 59: 693-698
    CrossrefPubMedSearch in Google Scholar
  • 7 Cantos E, Espin JC, Lopez-Bote C. et al. Phenolic compounds and fatty acids from acorns (Quercus spp.), the main dietary constituent of free-ranged Iberian pigs. J Agric Food Chem 2003; 51: 6248-6255
    CrossrefPubMedSearch in Google Scholar
  • 8 Cassir N, Rolain JM, Brouqui P. A new strategy to fight antimicrobial resistance: the revival of old antibiotics. Front Microbiol 2014; 5: 551
    CrossrefPubMedSearch in Google Scholar
  • 9 Cousins BW, Tanksley TD, Knabe DA, Zebrowska T. Nutrient digestibility and performance of pigs fed sorghums varying in tannin concentration. J Anim Sci 1981; 53: 1524-1537
    CrossrefPubMedSearch in Google Scholar
  • 10 Croxen MA, Law RJ, Scholz R. et al. Recent advances in understanding enteric pathogenic Escherichia coli . Clin Microbiol Rev 2013; 26: 822-880
    CrossrefPubMedSearch in Google Scholar
  • 11 Dadi TH, Vahjen W, Zentek J. et al. Lythrum salicaria L. herb and gut microbiota of healthy post-weaning piglets. Focus on prebiotic properties and formation of postbiotic metabolites in ex vivo cultures. J Ethnopharmacol 2020; 261: 113073
    CrossrefPubMedSearch in Google Scholar
  • 12 Espin JC, Gonzalez-Barrio R, Cerda B. et al. Iberian pig as a model to clarify obscure points in the bioavailability and metabolism of ellagitannins in humans. J Agric Food Chem 2007; 55: 10476-10485
    CrossrefPubMedSearch in Google Scholar
  • 13 Ferguson NS, Gous RM, Iji PA. Determining the source of anti-nutritional factor(s) found in two species of lupin (L-albus and L-angustifolius) fed to growing pigs. Livest Prod Sci 2003; 84: 83-91
    CrossrefSearch in Google Scholar
  • 14 Girard M, Thanner S, Pradervand N. et al. Hydrolysable chestnut tannins for reduction of postweaning diarrhea: Efficacy on an experimental ETEC F4 model. PLoS One 2018; 13: e0197878
    CrossrefPubMedSearch in Google Scholar
  • 15 Girard M, Bee G. Invited review: Tannins as a potential alternative to antibiotics to prevent coliform diarrhea in weaned pigs. Animal 2020; 14: 95-107
    CrossrefPubMedSearch in Google Scholar
  • 16 Granica S, Vahjen W, Zentek J. et al. Lythrum salicaria L. ellagitannins stimulate IPEC-J2 cells monolayer formation and inhibit enteropathogenic Escherichia coli growth and adhesion. J Nat Prod 2020; 83: 3614-3622
    CrossrefPubMedSearch in Google Scholar
  • 17 Gyles CL, Prescott JF, Songer JG, Thoen CO. Pathogenesis of Bacterial Infections in Animals. 4th ed. Wiley-Blackwell Publishing; 2010
    CrossrefSearch in Google Scholar
  • 18 Harvey AL, Edrada-Ebel R, Quinn RJ. The re-emergence of natural products for drug discovery in the genomics era. Nat Rev Drug Discov 2015; 14: 111-129
    CrossrefPubMedSearch in Google Scholar
  • 19 Huang Q, Liu X, Zhao G, Hu T, Wang Y. Potential and challenges of tannins as an alternative to in-feed antibiotics for farm animal production. Anim Nutr 2018; 4: 137-150
    CrossrefPubMedSearch in Google Scholar
  • 20 Jukes TH, Stokstad ELR, Taylor RR. et al. GROWTH-promoting effect of aureomycin on pigs. Arch Biochem 1950; 26: 324-325
    PubMedSearch in Google Scholar
  • 21 Kamada N, Seo SU, Chen GY, Nunez G. Role of the gut microbiota in immunity and inflammatory disease. Nat Rev Immunol 2013; 13: 321-335
    CrossrefPubMedSearch in Google Scholar
  • 22 Lee SH, Shinde PL, Choi JY. et al. Effects of tannic acid supplementation on growth performance, blood hematology, iron status and faecal microflora in weanling pigs. Livest Sci 2010; 131: 281-286
    CrossrefSearch in Google Scholar
  • 23 Lekagul A, Tangcharoensathien V, Yeung S. Patterns of antibiotic use in global pig production: A systematic review. Vet Anim Sci 2019; 7: 100058
    CrossrefPubMedSearch in Google Scholar
  • 24 Mangan JL. Nutritional effects of tannins in animal feeds. Nutr Res Rev 1988; 1: 209-239
    CrossrefPubMedSearch in Google Scholar
  • 25 Mariscal-Landin G, Lebreton Y, Seve B. Apparent and standardised true ileal digestibility of protein and amino acids from faba bean, lupin and pea, provided as whole seeds, dehulled or extruded in pig diets. Anim Feed Sci Tech 2002; 97: 183-198
    CrossrefSearch in Google Scholar
  • 26 McAllister TA, Martinez T, Bae HD. et al. Characterization of condensed tannins purified from legume forages: chromophore production, protein precipitation, and inhibitory effects on cellulose digestion. J Chem Ecol 2005; 31: 2049-2068
    CrossrefPubMedSearch in Google Scholar
  • 27 Mena P, Bresciani L, Brindani N. et al. Phenyl-gamma-valerolactones and phenylvaleric acids, the main colonic metabolites of flavan-3-ols: synthesis, analysis, bioavailability, and bioactivity. Nat Prod Rep 2019; 36: 714-752
    CrossrefPubMedSearch in Google Scholar
  • 28 Mueller-Harvey I. Unravelling the conundrum of tannins in animal nutrition and health. J Sci Food Agr 2006; 86: 2010-2037
    CrossrefSearch in Google Scholar
  • 29 Nagy B, Fekete PZ. Enterotoxigenic Escherichia coli in veterinary medicine. Int J Med Microbiol 2005; 295: 443-454
    CrossrefPubMedSearch in Google Scholar
  • 30 Piwowarski JP, Kiss AK, Kozlowska-Wojciechowska M. Anti-hyaluronidase and anti-elastase activity screening of tannin-rich plant materials used in traditional Polish medicine for external treatment of diseases with inflammatory background. J Ethnopharmacol 2011; 137: 937-941
    CrossrefPubMedSearch in Google Scholar
  • 31 Piwowarski JP, Granica S, Zwierzynska M. et al. Role of human gut microbiota metabolism in the anti-inflammatory effect of traditionally used ellagitannin-rich plant materials. J Ethnopharmacol 2014; 155: 801-809
    CrossrefPubMedSearch in Google Scholar
  • 32 Piwowarski JP, Granica S, Kiss AK. Lythrum salicaria L. – Underestimated medicinal plant from European traditional medicine. A review. J Ethnopharmacol 2015; 170: 226-250
    CrossrefPubMedSearch in Google Scholar
  • 33 Piwowarski JP, Kiss AK. Contribution of C-glucosidic ellagitannins to Lythrum salicaria L. influence on pro-inflammatory functions of human neutrophils. J Nat Med 2015; 69: 100-110
    CrossrefPubMedSearch in Google Scholar
  • 34 Piwowarski JP, Granica S, Stefanska J, Kiss AK. Differences in metabolism of ellagitannins by human gut microbiota ex vivo cultures. J Nat Prod 2016; 79: 3022-3030
    CrossrefPubMedSearch in Google Scholar
  • 35 Piwowarski JP, Stanislawska I, Granica S. et al. Phase II conjugates of urolithins isolated from human urine and potential role of beta-glucuronidases in their disposition. Drug Metab Dispos 2017; 45: 657-665
    CrossrefPubMedSearch in Google Scholar
  • 36 Redondo LM, Chacana PA, Dominguez JE, Fernandez Miyakawa ME. Perspectives in the use of tannins as alternative to antimicrobial growth promoter factors in poultry. Front Microbiol 2014; 5: 118
    CrossrefPubMedSearch in Google Scholar
  • 37 Stukelj M, Valencak Z, Krsnik M, Svete AN. The effect of the combination of acids and tannin in diet on the performance and selected biochemical, haematological and antioxidant enzyme parameters in grower pigs. Acta Vet Scand 2010; 52: 19
    CrossrefPubMedSearch in Google Scholar
  • 38 Tomas-Barberan FA, Gonzalez-Sarrias A, Garcia-Villalba R. et al. Urolithins, the rescue of "old" metabolites to understand a “new” concept: Metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health status. Mol Nutr Food Res 2017; 61
    CrossrefPubMedSearch in Google Scholar
  • 39 Van der Poel AF, Dellaert LM, Van Norel A, Helsper JP. The digestibility in piglets of faba bean (Vicia faba L.) as affected by breeding towards the absence of condensed tannins. Br J Nutr 1992; 68: 793-800
    CrossrefPubMedSearch in Google Scholar
  • 40 Xiong X, Tan B, Song M. et al. Nutritional intervention for the intestinal development and health of weaned pigs. Front Vet Sci 2019; 6: 46
    CrossrefPubMedSearch in Google Scholar
  • 41 Yamada H, Wakamori S, Hirokane T. et al. Structural revisions in natural ellagitannins. Molecules 2018; 23: 1901
    CrossrefPubMedSearch in Google Scholar
  • 42 Zhang L, Wang Y, Li D. et al. The absorption, distribution, metabolism and excretion of procyanidins. Food Funct 2016; 7: 1273-1281
    CrossrefPubMedSearch in Google Scholar