Transition-Metal-Catalyzed Asymmetric Reduction of 2-Pyridine Ketones

Vidhul Vasudevan; M S Harishankar; Thierry Ollevier

doi:10.1055/a-2501-4247

SynOpen, Table of Contents

CC BY 4.0 · SynOpen 2024; 08(04): 387-400
DOI: 10.1055/a-2501-4247

graphical review

Transition-Metal-Catalyzed Asymmetric Reduction of 2-Pyridine Ketones

Vidhul Vasudevan

,

M S Harishankar

,

Thierry Ollevier ∗

Abstract

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Abstract

This graphical review provides a concise overview of transition-metal-catalyzed asymmetric reduction of 2-pyridine ketones to produce enantiopure chiral 2-pyridine aryl/alkyl alcohols, which are present in many chiral ligands and pharmaceuticals. Key methods include metal-catalyzed hydrogenation, transfer hydrogenation, and hydrosilylation, with a focus on sustainable catalysts like iron and manganese. This review serves as a foundation for future advancements in sustainable and enantioselective keto group reductions.

Key words

asymmetric reduction - ketones - transfer hydrogenation - hydrogenation - hydrosilylation - iron catalysis

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References

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