This article is dedicated to Prof. B. C. Ranu on the grand occasion of his 75th birthday
Abstract
Recent developments in the synthesis of functionalized pyrazolo[1,5-a]pyrimidines through C–H functionalization have been summarized in this account, covering
the synthesis of 3-halo, 3-nitro, 3-formyl, 3-acetyl, 3-sulfenyl, 3-selenyl, and 3-thiocyanato
pyrazolo[1,5-a]pyrimidines and bis(pyrazolo[1,5-a]pyrimidin-3-yl)methanes. The main focus highlights the utilization of sustainable
conditions in designing the protocols. Mechanistic aspects of these protocols have
also been discussed in detail.
1 Introduction
2 Discussion
2.1 Synthesis of 3-Halo Pyrazolo[1,5-a]pyrimidines
2.2 Synthesis of 3-Nitro Pyrazolo[1,5-a]pyrimidines
2.3 Synthesis of 3-Formyl Pyrazolo[1,5-a]pyrimidine
2.4 Synthesis of 3-Acetyl Pyrazolo[1,5-a]pyrimidines
2.5 Synthesis of 3-Sulfenyl Pyrazolo[1,5-a]pyrimidines
2.6 Synthesis of 3-Selenyl Pyrazolo[1,5-a]pyrimidines
2.7 Synthesis of 3-Thiocyanated Pyrazolo[1,5-a]pyrimidines
2.8 Synthesis of Bis(pyrazolo[1,5-a]pyrimidinyl)methanes
3 Conclusions and Outcome
Key words
pyrazolo[1,5-
a]pyrimidines - C–H functionalization - photocatalysis - electrocatalysis - green chemistry
