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Pneumologie 2025; 79(11): 863-865
DOI: 10.1055/a-2606-1761
Leitlinie

Kurzfassung des Updates der S3-Leitlinie: Epidemiologie, Diagnostik und Therapie erwachsener Patienten mit nosokomialer Pneumonie

Summary of the update to the S3 guideline: Epidemiology, diagnosis and treatment of adult patients with nosocomial pneumonia

Autoren

  • Jessica Rademacher

     1   Department of Respiratory Medicine and German Centre of Lung Research (DZL), Hannover Medical School, Hannover, Germany

  • Santiago Ewig

     2   Thoraxzentrum Ruhrgebiet, Department of Respiratory and Infectious Diseases, EVK Herne and Augusta-Kranken-Anstalt Bochum, Bochum, Germany

  • Béatrice Grabein

     3   LMU Hospital, Clinical Microbiology and Hospital Hygiene, Munich, Germany

  • Irit Nachtigall

     4   Division of Infectious Diseases and Infection Prevention, Helios Hospital Emil-Von-Behring, Berlin, Germany

  • Marianne Abele-Horn

     5   Institute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany

  • Maria Deja

     6   Department of Anesthesiology and Intensive Care Medicine, University Medical Center Schleswig-Holstein, Berlin, Lübeck, Germany

  • Martina Gaßner

     7   Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Anaesthesiology and Intensive Care Medicine, Berlin, Germany

  • Sören Gatermann

     8   National Reference Centre for multidrug-resistant Gram-negative bacteria, Department of Medical Microbiology, Ruhr-University Bochum, Bochum, Germany

  • Christine Geffers

     9   Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Hygiene and Environmental Medicine, Berlin, Germany

  • Herwig Gerlach

    10   Department for Anaesthesia, Intensive Care Medicine and Pain Management, Vivantes-Klinikum Neukoelln, Berlin, Germany

  • Stefan Hagel

    11   Jena University Hospital-Friedrich Schiller University Jena, Institute for Infectious Diseases and Infection Control, Jena, Germany

  • Claus Peter Heußel

    12   Diagnostic and Interventional Radiology, Heidelberg, University Hospital, Heidelberg, Germany

  • Stefan Kluge

    13   Department of Intensive Care, University Hospital Hamburg-Eppendorf, Hamburg, Germany

  • Martin Kolditz

    14   Medical Department 1, Division of Pulmonology, University Hospital of TU Dresden, Dresden, Germany

  • Evelyn Kramme

    15   Department of Infectious Diseases and Microbiology, University of Lübeck and University Hospital Schleswig-Holstein, Campus Lübeck, Germany

  • Hilmar Kühl

    16   Department of Radiology, St. Bernhard-Hospital Kamp-Lintfort, Kamp-Lintfort, Germany

  • Marcus Panning

    17   Institute of Virology, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

  • Peter-Michael Rath

    18   Institute for Medical Microbiology, University Medicine Essen, Essen, Germany

  • Gernot Rohde

    19   Department of Respiratory Medicine, Goethe University Frankfurt, University Hospital, Frankfurt/Main, Germany

  • Bernhard Schaaf

    20   Department of Respiratory Medicine and Infectious Diseases, Klinikum Dortmund, Dortmund, Germany

  • Helmut J.F. Salzer

    21   Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine-Pneumology, Kepler University Hospital, Medical Faculty, Johannes Kepler University, Linz, Austria

  • Dierk Schreiter

    22   Helios Park Clinic, Department of Intensive Care Medicine, Leipzig, Germany

  • Hans Schweisfurth

    23   Institute for Pulmonary Research (IPR), Cottbus, Germany

  • Susanne Unverzagt

    24   Institute of General Practice and Family Medicine, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany

  • Markus A.Weigand

    25   Medical Faculty Heidelberg, Department of Anesthesiology, Heidelberg University, Heidelberg, Germany

  • Tobias Welte

     1   Department of Respiratory Medicine and German Centre of Lung Research (DZL), Hannover Medical School, Hannover, Germany

  • Mathias W. Pletz

    11   Jena University Hospital-Friedrich Schiller University Jena, Institute for Infectious Diseases and Infection Control, Jena, Germany
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Zusammenfassung

Die im Januar 2024 aktualisierte S3-Leitlinie zur „Epidemiologie, Diagnostik und Therapie erwachsener Patienten mit nosokomialer Pneumonie“ bietet evidenzbasierte Empfehlungen zur Verbesserung der Versorgung dieser häufigen Krankenhausinfektion. Sie ersetzt die Version von 2017 und wurde unter Beteiligung von 14 Fachgesellschaften überarbeitet. Die Leitlinie umfasst 26 Empfehlungen, etwa zur differenzierten Diagnostik (inkl. Multiplex-PCR, BAL, Biomarkern) und zur kalkulierten antimikrobiellen Therapie. Sie betont kürzere Therapiedauern, gezielte Einsatzindikationen für Kombinationstherapien und moderne Konzepte wie Antibiotic Stewardship. Neu sind Empfehlungen zu viralen und fungalen Erregern sowie ein Flussdiagramm zur initialen Therapieentscheidung. Die Gültigkeit der Leitlinie reicht bis Februar 2029.

Abstract

The updated S3 guideline on the “Epidemiology, Diagnosis and Treatment of Adult Patients with Nosocomial Pneumonia”, published in January 2024, provides evidence- and consensus-based recommendations aimed at improving care for this prevalent hospital-acquired infection. Replacing the 2017 version, the guideline was developed through an interdisciplinary process involving 14 professional societies. It includes 26 recommendations, covering extended diagnostic strategies (including multiplex PCR, biomarkers, and BAL) and tailored antimicrobial therapy. Key innovations include shortened treatment durations, targeted use of combination regimens, integration of viral and fungal pathogens, and a flowchart to guide empirical therapy. Emphasis is placed on antibiotic stewardship, reevaluation strategies, and resistance management. The guideline remains valid until February 2029.



Publikationsverlauf

Artikel online veröffentlicht:
21. November 2025

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