Assessing Olfactory Bulb Infiltration and Morphological Changes in Olfactory Neuroblastoma Using Magnetic Resonance Imaging

Teppei Takeda; Yasine Mirmozaffari; Teru Ebihara; Takeshi Kawasaki; Kazuhiro Omura; Adam J. Kimple; Brent A. Senior; Nobuyoshi Otori; Charles Ebert; Christine Klatt-Cromwell; Brian D. Thorp

doi:10.1055/a-2607-5757

Journal of Neurological Surgery Part B: Skull Base, Table of Contents

J Neurol Surg B Skull Base
DOI: 10.1055/a-2607-5757

Original Article

Assessing Olfactory Bulb Infiltration and Morphological Changes in Olfactory Neuroblastoma Using Magnetic Resonance Imaging

Teppei Takeda

¹Department of Otorhinolaryngology, The Jikei University School of Medicine, Tokyo, Japan

²Department of Otolaryngology—Head and Neck Surgery, University of North Carolina, Chapel Hill, North Carolina, United States

,

Yasine Mirmozaffari

²Department of Otolaryngology—Head and Neck Surgery, University of North Carolina, Chapel Hill, North Carolina, United States

,

Teru Ebihara

¹Department of Otorhinolaryngology, The Jikei University School of Medicine, Tokyo, Japan

,

Takeshi Kawasaki

¹Department of Otorhinolaryngology, The Jikei University School of Medicine, Tokyo, Japan

,

Kazuhiro Omura

¹Department of Otorhinolaryngology, The Jikei University School of Medicine, Tokyo, Japan

,

Adam J. Kimple

²Department of Otolaryngology—Head and Neck Surgery, University of North Carolina, Chapel Hill, North Carolina, United States

,

Brent A. Senior

²Department of Otolaryngology—Head and Neck Surgery, University of North Carolina, Chapel Hill, North Carolina, United States

,

Nobuyoshi Otori

¹Department of Otorhinolaryngology, The Jikei University School of Medicine, Tokyo, Japan

,

Charles Ebert

²Department of Otolaryngology—Head and Neck Surgery, University of North Carolina, Chapel Hill, North Carolina, United States

,

Christine Klatt-Cromwell

²Department of Otolaryngology—Head and Neck Surgery, University of North Carolina, Chapel Hill, North Carolina, United States

,

Brian D. Thorp

²Department of Otolaryngology—Head and Neck Surgery, University of North Carolina, Chapel Hill, North Carolina, United States

› Author Affiliations

Abstract

Objectives

This study aimed to evaluate magnetic resonance imaging (MRI)-based changes in olfactory bulb (OB) volume and area to predict the likelihood of OB invasion in olfactory neuroblastoma (ONB).

Design

Retrospective review of MRI data.

Setting

This study was conducted at the Jikei University, Japan, and the University of North Carolina, United States.

Participants

The study included 46 ONB-diagnosed patients undergoing MRI and surgical treatment.

Main Outcome Measures

Preoperative volume and cross-sectional area of the OB were measured, and the surgical pathology of the OB was reviewed.

Results

Significant differences in OB metrics were observed between patients with and without OB/tract invasions. Receiver operating characteristic analysis demonstrated high discriminative ability: OB volume (area under the curve [AUC] = 0.971, cutoff 60 mm³) and maximum cross-sectional area (AUC = 0.941, cutoff 9.5 mm²) both showed high sensitivity and specificity for predicting OB invasion. The left–right OB difference, with a lesion/nonlesion ratio exceeding 175%, was a strong predictor.

Conclusion

Quantitative MRI metrics of the OB are effective in predicting invasion in ONB. These findings may enhance diagnostic accuracy and influence treatment strategies. Further research is warranted to validate these findings in larger cohorts.

Keywords

olfactory neuroblastoma - MRI - olfactory bulb - tumor invasion - predictive model - ROC analysis - diagnostic accuracy

Full Text

References

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