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DOI: 10.1055/a-2648-9142
Solvent-Dependent Synthesis of Perlin Aldehyde from d-Glucal Using Ceric Ammonium Nitrate and TMSCl
Authors
Y.Y. is thankful to the Prime Minister Research Fellowship (PMRF), Ministry of Education (MoE), India. A.T. is grateful to Jawaharlal Nehru University (JNU) for merit-cum-means (MCM) scholarship. K.S. is thankful to the Council of Scientific and Industrial Research (CSIR), India for Senior Research Fellowship. The authors thank Jawaharlal Nehru University (JNU) for providing research facilities to carry out this work.
Abstract
In this study, a solvent-dependent ceric ammonium nitrate (CAN) and TMSCl-mediated synthesis of enantiopure 2,3-dideoxy-α,β-unsaturated carbohydrate enals (Perlin aldehydes) in CH3CN and 1,4-dioxane has been reported. This efficient protocol works well for the various d-glucals (O-acetyl, O-propyl, O-butyl, O-TIPS), and afforded Perlin aldehyde in acceptable to good yields. Thus, in this article we present a quick, efficient, and highly selective method for synthesizing Perlin aldehyde in 1.5 h at 70 °C in good yield.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2648-9142.
- Supporting Information (PDF)
Publikationsverlauf
Eingereicht: 03. Mai 2025
Angenommen nach Revision: 03. Juli 2025
Accepted Manuscript online:
03. Juli 2025
Artikel online veröffentlicht:
22. Juli 2025
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