Tailored-Designed Ligands for Enantioselective Gold(I)-Catalyzed Activation of Alkynes

Pablo Mora; Imma Escofet; Antonio Echavarren

doi:10.1055/a-2650-6278

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CC BY-NC-ND 4.0 · Synlett
DOI: 10.1055/a-2650-6278

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Tailored-Designed Ligands for Enantioselective Gold(I)-Catalyzed Activation of Alkynes

Authors

Pablo Mora

¹Institute of Chemical Research of Catalonia (ICIQ), Barcelona Institute of Science and Technology, Tarragona, Spain

²Departament de Química Orgànica i Analítica, Universitat Rovira i Virgili, C/Marcel·lí Domingo s/n, Tarragona, Spain
Imma Escofet

¹Institute of Chemical Research of Catalonia (ICIQ), Barcelona Institute of Science and Technology, Tarragona, Spain
Antonio Echavarren

¹Institute of Chemical Research of Catalonia (ICIQ), Barcelona Institute of Science and Technology, Tarragona, Spain

²Departament de Química Orgànica i Analítica, Universitat Rovira i Virgili, C/Marcel·lí Domingo s/n, Tarragona, Spain

Abstract

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Abstract

In this article, we describe the work performed at our laboratories over the years on the design and applications of novel chiral ligands for the enantioselective gold(I)-catalyzed activation of alkynes, with a focus on the cycloisomerization and cycloaddition reactions of 1,6-enynes. The rationale behind the development of each ligand and the mode of enantioinduction are discussed.

Keywords

Chiral ligands - Enantioselective synthesis - Gold catalysis - Enynes - Alkynes

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References

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