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Synlett
DOI: 10.1055/a-2669-6192
DOI: 10.1055/a-2669-6192
Account
Alkynes in Organic Synthesis
Alkyne-Based Cascade Strategies for the Construction of Diverse Carbo/Heterocycles
This work is supported by the Science and Engineering Research Board (SERB) [File Number. CRG/2023/000775], Government of India.
Supported by: Government of India
Supported by: Indian Institute of Technology Hyderabad
Supported by: University Grants Commission (UGC), New Delhi
Abstract
Carbocycles/heterocycles are fundamental structural motifs in natural products, pharmaceuticals, and functional materials. Alkyne-based cascade strategies have emerged as powerful tools for the efficient construction of these frameworks, enabling rapid access to diverse ring systems through domino cyclization pathways. This account highlights the representative recent advances of alkyne-mediated cascade reactions, covering transition-metal catalysis and acid-mediated reactions. These methods facilitate multiple bond-forming events in a single operation, offering high atom and step economy. Special focus is given to illustrative transformations, mechanistic insights, and the broad utility of alkynes as precursors for the concise synthesis of diverse carbocyclic and heterocyclic molecular frameworks.
Publication History
Received: 30 June 2025
Accepted after revision: 28 July 2025
Accepted Manuscript online:
29 July 2025
Article published online:
17 September 2025
© 2025. Thieme. All rights reserved.
Georg Thieme Verlag KG
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