Abstract
Significant research efforts have been devoted to the synthesis of substituted phospholes
due to their exceptional optical and physical properties. In contrast to conventional
methods, the direct C−H functionalizations of readily accessible phospholes offer
an efficient and modular route to structurally diverse phosphole derivatives. In this
account, we present our research group’s advancements in the regioselective C−H functionalizations
of benzophospholes, including: (1) palladium-catalyzed C−H arylation, alkenylation,
and alkynylation; (2) organophotoredox-catalyzed C−H alkoxycarbonylation, phosphinylation,
and alkylation; and (3) related photo-promoted dehydrogenative cyclization and palladium-catalyzed
annulative π-extension.
Keywords
Annulation - Benzophosphole - C−H functionalization - Heterocycles - Organophotocatalysis
- Mallory reaction - Palladium catalysis
