Unravelling the Synthesis of Benzo[d]imidazo[2,1-b]thiazoles via MnO₂/I₂-Catalyzed Ortoleva-King Type Approach

Dedication

Dedicated with profound reverence to Dr. Vijay Nair on the occasion of his first death anniversary.

Abstract

The first MnO₂/I₂-catalyzed one-pot synthesis of benzo[d]imidazo[2,1-b]thiazole from 2-aminobenzothiazole and aryl methyl ketone has been described. This methodology involves the in situ generation of α-iodoketone from aryl methyl ketone in the presence of a catalytic amount of molecular iodine. An array of aromatic ketones and 2-aminobenzothiazoles were compatible with this strategy, providing diverse fused benzoimidazothiazoles in moderate to good yields.

Keywords

Benzo[d]imidazo[2,1-b]thiazole - Aryl methyl ketone - 2-Aminobenzothiazole - Ortoleva-King type reaction - Manganese - Iodide source

Publikationsverlauf

Eingereicht: 24. Mai 2025

Angenommen nach Revision: 08. August 2025

Artikel online veröffentlicht:
26. August 2025

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