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CC BY 4.0 · Endosc Int Open
DOI: 10.1055/a-2712-9822
Original article

Enhancing Comprehensive Genome Profiling of Liver Tumors Using Endoscopic Ultrasound-Guided Fine-Needle Biopsy

Authors

  • Fumitaka Niiya 

    1   Internal Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan (Ringgold ID: RIN26858)

  • Akihiro Nakamura

    2   Division of Pathology, Showa Medical University Fujigaoka Hospital, Yokohama, Japan (Ringgold ID: RIN26858)

  • Yasuo Ueda

    2   Division of Pathology, Showa Medical University Fujigaoka Hospital, Yokohama, Japan (Ringgold ID: RIN26858)

  • Takafumi Ogawa

    2   Division of Pathology, Showa Medical University Fujigaoka Hospital, Yokohama, Japan (Ringgold ID: RIN26858)

  • Naoki Tamai

    3   Division of Gastroenterology, Department of Internal Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan (Ringgold ID: RIN26858)

  • Masataka Yamawaki

    4   Showa Daigaku Fujigaoka Byoin, Yokohama, Japan (Ringgold ID: RIN26858)

  • Jun Noda 

    5   Gastroentelogy, Showa University Fujigaoka Hospital, Yokohama, Japan (Ringgold ID: RIN26858)

  • Tetsushi Azami

    6   Gastroenterology, Showa University Fujigaoka Hospital, Yokohama, Japan (Ringgold ID: RIN26858)

  • Yuichi Takano 

    7   gastroenterology, showa university fujigaoka hospital, Yokohama, Japan

  • Masatsugu Nagahama

    8   Division of Gastroenterology, showa university fujigaoka hospital, Yokohama, Japan
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Background/study aim: Comprehensive genome profiling (CGP) is gaining importance in the management of biliary and pancreatic cancers; therefore, obtaining ideal tissue samples is critical. Although percutaneous biopsy has been the first-line method of sampling liver tumors, recent advancements in endoscopic ultrasound (EUS)-guided tissue acquisition (EUS-TA), particularly the introduction of fine-needle biopsy (FNB) needles capable of obtaining larger tissue samples, suggest that EUS-TA may be an alternative for obtaining ideal specimens for CGP. However, few studies have evaluated the utility of EUS-TA with CGP for liver tumors. This study aimed to assess the role of EUS-guided FNB (EUS-FNB) in the collection of ideal liver tumor samples for CGP and analyses. Patients and Methods: This retrospective study included 36 patients with liver tumors who underwent EUS-FNB. The histological diagnostic accuracy, rate of obtaining ideal samples for CGP, and impact of procedural factors, such as needle gauge, tumor size, and number of punctures, were analyzed. Results: EUS-TA achieved a histological diagnostic accuracy rate of 94.4%, and the rate of obtaining ideal samples for CGP was 63.9%. A subgroup analysis showed that 22-gauge (70.4%) and 19-gauge (100%) needles were significantly more effective than 25-gauge needles (16.7%) for obtaining ideal samples for CGP (P = 0.025 and P = 0.048, respectively). No adverse events were observed during or after sampling. Conclusions: EUS-FNB is highly effective for obtaining ideal samples for CGP and achieving an accurate histological diagnosis. The 22-gauge and 19-gauge needles were significantly superior to 25-gauge needles, thus emphasizing their importance in precision medicine.



Publikationsverlauf

Eingereicht: 25. Mai 2025

Angenommen nach Revision: 22. September 2025

Accepted Manuscript online:
29. September 2025

© . The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).

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Bibliographical Record
Fumitaka Niiya, Akihiro Nakamura, Yasuo Ueda, Takafumi Ogawa, Naoki Tamai, Masataka Yamawaki, Jun Noda, Tetsushi Azami, Yuichi Takano, Masatsugu Nagahama. Enhancing Comprehensive Genome Profiling of Liver Tumors Using Endoscopic Ultrasound-Guided Fine-Needle Biopsy. Endosc Int Open ; 0: a27129822.
DOI: 10.1055/a-2712-9822