Cp2TiCl-Mediated 5-exo-trig Radical Cyclization in Epoxy-Appended Olefin Diesters: Towards the Synthesis of Lingzhilactones

The Cp2TiCl-mediated opening of epoxides in α,β-unsaturated ester-appended substrates leads to a cascading 5-exo-trig radical cyclization followed by lactonization yielding bicyclic lactone rings. Leveraging this strategic approach has become crucial in the construction of the core structure of many terpenoid natural products. In our present study, this methodology is further extended to the maleate/fumerate diester appended substrates to give selectively only the 5-exo ring closure products with [5,5] bicyclic lactone framework. This arranged the basis of a facile approach to attempt the synthesis of lingzhilactone B, an important Ganoderma meroterpenoid with two all-carbon quaternary chiral centers in the ring junction, from easily available starting material. The modular strategy developed here can pave the synthetic pathways for many other natural products of this genre.

Publication History

Received: 03 October 2025

Accepted after revision: 27 October 2025

Accepted Manuscript online:
27 October 2025