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CC BY 4.0 · SynOpen
DOI: 10.1055/a-2741-0910
Graphical Review

Recent Advances in the Synthesis of Axially Chiral Cycloalkanes

Authors

  • Tonglin Zhao

    1   State Key Laboratory of Biotherapy and West China School of Public Health, Sichuan University, Chengdu, China (Ringgold ID: RIN12530)

  • Ling Chen

    1   State Key Laboratory of Biotherapy and West China School of Public Health, Sichuan University, Chengdu, China (Ringgold ID: RIN12530)

  • Xufei Yan

    1   State Key Laboratory of Biotherapy and West China School of Public Health, Sichuan University, Chengdu, China (Ringgold ID: RIN12530)

  • Ying Xia 

    1   State Key Laboratory of Biotherapy and West China School of Public Health, Sichuan University, Chengdu, China (Ringgold ID: RIN12530)

Supported by: Thousand Young Talents Program of China 15-YINGXIA
Supported by: National Natural Science Foundation of China 22301194,22371189
Supported by: Natural Science Foundation of Sichuan Province 2025ZNSFSC0918
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Axially chiral cycloalkanes have recently emerged as compelling scaffolds with broad utility in asymmetric catalysis and molecular design. This review provides a concise and graphical overview of synthetic strategies for constructing axially chiral cycloalkanesalkylidene-cyclic alkanes. Representative methods summarized include asymmetric allylic substitution, alkene insertion, carbene cross-coupling, carbonyl condensation/reduction, [2+2] cycloaddition, and deracemization. We aim to offer fundamental insights into this emerging field and facilitate future research toward novel chiral frameworks.



Publication History

Received: 23 September 2025

Accepted after revision: 03 November 2025

Accepted Manuscript online:
06 November 2025

© . The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).

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