Electrochemical Oxidation of Benzylic C(sp3)–H Bonds Presents a Versatile Metal-Free Approach for the Synthesis of Enones

Issa Yavari; Sina Shaabanzadeh

doi:10.1055/a-2741-3358

Synthesis, Table of Contents

Synthesis
DOI: 10.1055/a-2741-3358

Paper

Electrochemical Oxidation of Benzylic C(sp³)–H Bonds Presents a Versatile Metal-Free Approach for the Synthesis of Enones

Authors

Issa Yavari

¹Department of Chemistry, Tarbiat Modares University, Tehran, Iran (the Islamic Republic of) (Ringgold ID: RIN41616)
Sina Shaabanzadeh

¹Department of Chemistry, Tarbiat Modares University, Tehran, Iran (the Islamic Republic of) (Ringgold ID: RIN41616)

Abstract

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Abstract

An electrochemical approach has been developed for synthesizing enones with various functional groups through the electrooxidation of benzylic substrates in an aqueous solution containing a methyl ketone. This method eliminates the necessity for hazardous metal catalysts and external oxidants. It demonstrates impressive chemical yields ranging from 68% to 80%, is scalable for gram-scale production, and achieves Coulombic yields between 10% and 15%.

Keywords

Electrochemical oxidation - Enones - Benzylic C(sp³)–H bond - Methyl ketones - Aldol condensation

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References

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Supplementary Material

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