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Synthesis
DOI: 10.1055/a-2741-3358
DOI: 10.1055/a-2741-3358
Paper
Electrochemical Oxidation of Benzylic C(sp3)–H Bonds Presents a Versatile Metal-Free Approach for the Synthesis of Enones
Authors
We are grateful to the Research Council of Tarbiat Modares University for support of this work.
Abstract
An electrochemical approach has been developed for synthesizing enones with various functional groups through the electrooxidation of benzylic substrates in an aqueous solution containing a methyl ketone. This method eliminates the necessity for hazardous metal catalysts and external oxidants. It demonstrates impressive chemical yields ranging from 68% to 80%, is scalable for gram-scale production, and achieves Coulombic yields between 10% and 15%.
Keywords
Electrochemical oxidation - Enones - Benzylic C(sp3)–H bond - Methyl ketones - Aldol condensationPublication History
Received: 06 August 2025
Accepted after revision: 07 November 2025
Article published online:
01 December 2025
© 2025. Thieme. All rights reserved.
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