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Synlett
DOI: 10.1055/a-2770-5473
Letter

A new route of the oxidative cleavage of substituted carbonylfurans as an approach to 4-oxobutanoic acids

Autoren

  • Ilya Tkachenko 

    1   Organic chemistry, chemical-technological faculty, Samara State Technical University, Samara, Russian Federation (Ringgold ID: RIN65056)

  • Natalia Alexeevna Ivanova

    2   Organic chemistry, Samara State Technical University, Samara, Russian Federation (Ringgold ID: RIN65056)

  • Kristina Sergeevna Khrapovitskaya

    2   Organic chemistry, Samara State Technical University, Samara, Russian Federation (Ringgold ID: RIN65056)

  • Olga Lodochnikova 

    3   Laboratory of diffraction research methods, A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan, Russian Federation

  • Yuri Nikolaevich Klimochkin

    4   Department of Organic Chemistry, Samara State Technical University, Samara, Russian Federation

Gefördert durch: Russian Science Foundation 25-73-20144
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Novel approach to 4-oxobutanoic acids via the oxidative cleavage of 5-substituted 2-carbonylfurans is proposed. Optimization studies using various peroxide-based oxidation agents and other reaction conditions were performed. The obtained ketoacids have potential as precursors for synthesizing 4-substituted GABAanalogues and racetams. The synthetic potential of γ-ketoacids was demonstrated through a series of transformations involving 4-oxo-4-(adamantan-1-yl)butanoic acid as model substrate.



Publikationsverlauf

Eingereicht: 15. Oktober 2025

Angenommen nach Revision: 10. Dezember 2025

Accepted Manuscript online:
11. Dezember 2025

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