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Horm Metab Res 1976; 8(2): 114-117
DOI: 10.1055/s-0028-1093664
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© Georg Thieme Verlag KG Stuttgart · New York

Evaluation of the Antilipolytic Action of Clomiphene In Vitro[*]

C.-J.  Estler , P.  Mitznegg
  • Pharmakologisches Institut der Universität Erlangen-Nürnberg, Erlangen, Germany
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Publication History

Publication Date:
23 December 2008 (online)

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Abstract

Clomiphene (10-3 - 10-2 M) in a dose-dependent manner inhibited the lypolytic response of isolated rat epididymal adipose tissue and fat cells to epinephrine, ACTH, and dibutyryl-cyclic AMP. Furthermore, it reduced the non-hormonally stimulated activity of a crude preparation of lipase from epididymal adipose tissue. The accumulation of cyclic AMP produced by epinephrine in fat cells was not prevented by clomiphene at a concentration causing antilipolytic activity. It is concluded from these results that clomiphene unlike most other antilipolytic drugs exerts its antilipolytic effect by an inhibition of the lipase rather than by inhibition of adenylcyclase.

Key words

Lipolysis - Cyclic AMP - Clomiphene - Epinephrine - ACTH

1 The results have been presented at the Symposium of the Deutsche Gesellschaft für Endokrinologie, Tübingen 1974 and on the Frühjahrstagung der Deutschen Pharmakologischen Gesellschaft, Mainz 1974.

1 The results have been presented at the Symposium of the Deutsche Gesellschaft für Endokrinologie, Tübingen 1974 and on the Frühjahrstagung der Deutschen Pharmakologischen Gesellschaft, Mainz 1974.

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