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Horm Metab Res 1976; 8(2): 136-140
DOI: 10.1055/s-0028-1093669
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© Georg Thieme Verlag KG Stuttgart · New York

Effect of Salmon Calcitonin on Renal Excretion of Adenosine 3',5' Monophosphate in Man

R.  Ardaillou1 , R.  Isaac1 , M. P. Nivez1 , J. M. Kuhn2 , J. L. Cazor2 , J. P. Fillastre2
  • 1INSERM Research Unit 64, Hôpital Tenon, 4 rue de la Chine, Paris, France
  • 2Department of Nephrology, Hôpital Charles Nicolle, Rouen, France
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Publication History

Publication Date:
23 December 2008 (online)

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Abstract

Intravenous infusion of salmon calcitonin in six healthy subjects produced an increase in the plasma levels and urinary excretion of cyclic AMP. Cyclic AMP clearance diminished but remained higher than insulin clearance. Salmon calcitonin was also infused in six hypertensive patients with normal glomerular filtration rate. Arterial and renal venous plasma concentrations of cyclic AMP were clearly raised. The difference between both these concentrations was not significant in the control periods but became marked during the treatment and post treatment periods demonstrating a net extraction of cyclic AMP from plasma by the kidneys. Renal extraction of cyclic AMP was lower than its urinary excretion in the control periods whereas it was clearly higher after salmon calcitonin was given. This shows that salmon calcitonin stimulates the production of cyclic AMP in extra-renal tissues and that the excess of cyclic AMP formed is catabolized by the kidneys.

Key words

Cyclic AMP - Calcitonin - Renal Excretion - Parathyroid Hormone

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