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Horm Metab Res 1974; 6(3): 175-177
DOI: 10.1055/s-0028-1093866
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© Georg Thieme Verlag KG Stuttgart · New York

Antigenicity of Monocomponent Porcine Insulin in Rabbits

D.  Kumar , S. D. Mehtalia , L. V. Miller
  • Department of Medicine, Diabetes Section, School of Medicine, University of Southern California, Los Angeles, California, USA
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Publikationsdatum:
08. Januar 2009 (online)

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Abstract

Monocomponent and commercial porcine insulin preparations administered with Freund's adjuvant, induced insulin antibodies in rabbits. The results show that the proinsulin-like contaminants in commercial insulin are not the essential stimuli for insulin antibody formation, and that purification of insulin per se is not sufficient to render insulin non-immunogenic. The physical state of insulin is more important in its immunogenicity.

Key words

Monocomponent Insulin - Insulin Antibodies