Horm Metab Res 2009; 41(2): 132-136
DOI: 10.1055/s-0028-1119407
Original

© Georg Thieme Verlag KG Stuttgart · New York

Effect of Acarbose on Postmeal Mononuclear Blood Cell Response in Patients with Early Type 2 Diabetes: The AI(I)DA Study

M. Hanefeld 1 , F. Schaper 1 , C. Koehler 1 , S. Bergmann 2 , P. Ugocsai 3 , J. Stelzer 1 , G. Schmitz 3
  • 1Center for Clinical Studies, GWT Dresden, Dresden, Germany
  • 2Institute of Clinical Chemistry, Medical Faculty TU Dresden, Dresden, Germany
  • 3Institute of Clinical Chemistry, University Hospital Regensburg, Regensburg, Germany
Further Information

Publication History

received 24.09.2008

accepted 09.12.2008

Publication Date:
12 February 2009 (online)

Abstract

So far little is known about how the antidiabetic drugs acting at the level of gastrointestinal mucosa may affect immune and cellular response to food intake. The following study investigated the association between acarbose treatment and postprandial metabolism, immune- and inflammatory activity in patients with early type 2 diabetes: The Acarbose action on low grade Inflammation and Immune response in type 2 Diabetes on Atherosclerosis risk (AIIDA) study. Middle-aged patients (n=87) with early type 2 diabetes (2 h-plasma-glucose ≥11.1 mmol/l and/or HbA1c ≥6.5%) and sub-clinical inflammation (leucocytes ≥6.2 GPt/l and/or hsCRP ≥1.0 mg/l) underwent a mixed meal load (527 kcal). Metabolic parameters and markers of subclinical inflammation were measured at fasting (0′), 2 h-postprandial (2-hpp) and 4-hpp before and after 20 weeks of treatment with acarbose or placebo. Leukocytes and lymphocytes excursion after 20 weeks of treatment was significantly reduced with acarbose 4 h after testmeal [GPt/l] (7.5 vs. 7; p<0.05; and 2.29 vs. 2.14; p<0.05, respectively). Acarbose had only marginal effects on pp glucose, FFA, triglycerides, and insulin excursion. Biomarkers of inflammation (hsCRP, MBL, and PAI1) were not affected by acarbose. Multivariate analysis reveals only baseline leukocytes and of acarbose as independent determinant of 4-h leucocytes excursion. Postprandial metabolic and inflammatory parameters were strongly interrelated. These results suggest pleiotropic effects of acarbose, which may contribute to its vasoprotective potentials.

References

Correspondence

Prof. Dr. med. M. Hanefeld

Centre for Clinical Studies

GWT – TUD GmbH

Fiedlerstr. 34

01307 Dresden

Germany

Phone: +49/351/44 00 580

Fax: +49/351/44 00 581

Email: [email protected]