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Planta Med 2000; 66(1): 82-83
DOI: 10.1055/s-0029-1243117
Letter

© Georg Thieme Verlag Stuttgart · New York

Antihyperglycemic Acetylenic Glucosides from Bidens pilosa

Rosa P. Ubillas1 , 2 , Christopher D. Mendez1 , Shivanand D. Jolad1 , Jian Luo1 , Steven R. King1 , Thomas J. Carlson1 , Diana M. Fort1 ,*
  • 1Shaman Pharmaceuticals Inc., South San Francisco, California, U.S.A.
  • 2Current address: Phytera, Inc., Worcester, Massachusetts, U.S.A.
Further Information

Publication History

Received: March 4, 1999

Accepted: June 27, 1999

Publication Date:
24 November 2009 (online)

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Abstract

In vivo bioassay-guided fractionation of the aqueous alcohol extract of the aerial parts of Bidens pilosa Sch. Bip. var. radiata (Asteraceae) using C57BL/Ks-db/db mice as a model for type 2 diabetes, yielded two known polyacetylenic glucosides, identified as 2-β-D-glucopyranosyloxy-1-hydroxy-5(E)-tridecene-7,9,11-triyne (1) and 3-β-D-glucopyranosyloxy-1-hydroxy-6(E)-tetradecene-8,10,12-triyne (2). A 3 : 2 mixture of compounds 1 and 2 effected a significant drop in blood glucose.

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Dr. Diana M. Fort

Shaman Pharmaceuticals Inc.

213 E. Grand Ave.

South San Francisco

CA 94080

U.S.A

Email: dfort@shaman.com

Fax: +1-650-794-0408

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